Evidence map›Paper›PMID 41509501›Full record

ArticlebioRxiv : the preprint server for biology2025

Direct measurement of sub-kilobase chromatin structure reveals that linker histone H1 broadly compacts chromatin, with differential impact amongst epigenetic states.

Hera Canaj, Irene Duba, Andres Mansisidor, Andrew Scortea, Ryan Johnson, Hugo Pinto, Arnold Ou, Nicole Pagane, Juhee Pae, Dmitry Fyodorov and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hera CanajLaboratory of Genome Architecture and Dynamics, The Rockefeller University, New York, NY.
Irene DubaLaboratory of Genome Architecture and Dynamics, The Rockefeller University, New York, NY.
Andres MansisidorLaboratory of Genome Architecture and Dynamics, The Rockefeller University, New York, NY.
Andrew ScorteaLaboratory of Genome Architecture and Dynamics, The Rockefeller University, New York, NY.
Ryan JohnsonLaboratory of Genome Architecture and Dynamics, The Rockefeller University, New York, NY.
Hugo PintoDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY.
Arnold OuLaboratory of Genome Architecture and Dynamics, The Rockefeller University, New York, NY.
Nicole PaganeLaboratory of Genome Architecture and Dynamics, The Rockefeller University, New York, NY.
Juhee PaeLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY.
Dmitry FyodorovDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY.
Arthur I SkoultchiDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY.
Viviana I RiscaLaboratory of Genome Architecture and Dynamics, The Rockefeller University, New York, NY.ORCID 0000-0003-2670-8704

Funding

Cross-regulation between loop extrusion, chromatin fiber structure and chromatin-associated RNAsDP2GM150021 · NIGMS · ROCKEFELLER UNIVERSITY · PI RISCA, VIVIANA I · 2022 to 2025
$2.5M
Functions of Mammalian H1 Linker Histones in Gene Regulation and Chromatin ActivityR01GM147165 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SKOULTCHI, ARTHUR I · 2022 to 2025
$2.1M
Sperm chromatin structure and remodeling during spermiogenesis and fertilizationR01HD114814 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI DMITRY V FYODOROV · 2024 to 2026
$1.7M
NICHD NIH HHS R01 HD114814NIGMS NIH HHS DP2 GM150021NIGMS NIH HHS R01 GM147165
6 · The paper itself

Abstract

Chromatin compaction by linker histone H1 family proteins is a long-standing model for transcriptional repression. However, the biophysical and conformational details of such compaction

Identifiers

PMID41509501
PMCPMC12776130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.