Evidence map›Paper›PMID 41509497›Full record

ArticlebioRxiv : the preprint server for biology2025

Skin microbiome composition and function in the development of atopic diseases during infancy.

Zeyang Shen, Jana Eckert, Richard Saffery, Katrina J Allen, Audrey Walsh, VITALITY team, Clay Deming, Qiong Chen, Karen Laky, Jenny Min Li and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Zeyang ShenSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.ORCID 0000-0003-3870-1390
Jana EckertPopulation Allergy, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Richard SafferyCentre for Food and Allergy Research, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Katrina J AllenPopulation Allergy, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Audrey WalshPopulation Allergy, Murdoch Children's Research Institute, Parkville, VIC, Australia.
VITALITY team
Clay DemingMicrobial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
Qiong ChenMicrobial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
Karen LakyLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Jenny Min LiLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Lindsay ChatmanLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
NISC Comparative Sequencing Program
Heidi H KongDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA.
Kirsten P PerrettPopulation Allergy, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Julia A SegreMicrobial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
Pamela A Frischmeyer-GuerrerioLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.

Funding

Immune Tolerance Network UM1 2023 SupplementUM1AI109565 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI Mark S Anderson, Jane Hoyt Buckner · 2014 to 2026
$451.6M
Investigating the role of skin and gut microbiome in the onset of atopic dermatitis in infantsR00AR084058 · NIAMS · WASHINGTON STATE UNIVERSITY · PI Zeyang Shen · 2025 to 2026
$486k
NIAID NIH HHS UM1 AI109565NIAMS NIH HHS R00 AR084058
6 · The paper itself

Abstract

Background: Atopic dermatitis (AD), food sensitization (FS), and food allergy (FA) frequently co-occur in infancy, but the factors driving distinct atopic phenotypes remain unclear. While Objective: To determine how early-life skin microbiome composition and its interaction with host genetics contribute to distinct atopic phenotypes in infancy. Methods: We analyzed >1,000 skin swabs from 429 infants in the VITALITY cohort using deep shotgun metagenomic sequencing at 2-3 months (pre-diagnosis) and 12 months (post-diagnosis). Differential abundance, strain-level, and microbial genome-wide association analyses were performed to identify taxonomic and functional features associated with AD, FS, FA, and their co-occurrence, as well as with Results: Within AD, microbial signatures differed by co-occurring FA or FS. At 12 months, Conclusions: Infant atopic phenotypes are associated with distinct, phenotype-specific features of the skin microbiome that emerge both before and after clinical disease onset. By resolving microbial differences within AD according to allergic co-occurrence, host genetics, and early-life timing, this study highlights the infant skin microbiome as a potential target for early risk stratification.

Indexed as

atopic dermatitisearly lifeFLG mutationsfood allergyhost-microbiome interactionshotgun metagenomicsskin microbiome

Identifiers

PMID41509497
PMCPMC12776104

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.