Evidence map›Paper›PMID 41509481›Full record

ArticlebioRxiv : the preprint server for biology2026

Quenching corrinoid-based interactions in a model bacterial coculture.

Zachary F Hallberg, Zoila I Alvarez-Aponte, Alison C Gaudinier, Michiko E Taga

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Zachary F HallbergDepartment of Plant & Microbial Biology, University of California, Berkeley, Berkeley, CA, 94720 USA.ORCID 0000-0001-7732-2073
Zoila I Alvarez-AponteDepartment of Plant & Microbial Biology, University of California, Berkeley, Berkeley, CA, 94720 USA.
Alison C GaudinierDepartment of Plant & Microbial Biology, University of California, Berkeley, Berkeley, CA, 94720 USA.
Michiko E TagaDepartment of Plant & Microbial Biology, University of California, Berkeley, Berkeley, CA, 94720 USA.

Funding

Microbial Corrinoid Metabolism Across Scales: From Molecular Specificity to Community DynamicsR35GM139633 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Michiko E. Taga · 2021 to 2026
$3.0M
Bacterial Metabolic Exchanges in Gut Enrichment CultureK99GM143653 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HALLBERG, ZACHARY · 2022 to 2023
$215k
NIGMS NIH HHS K99 GM143653NIGMS NIH HHS R35 GM139633
6 · The paper itself

Abstract

Microbial community structure is driven, in part, by the metabolic interdependencies of resident microbes. Thus, manipulating specific metabolic interactions represents one attractive way to both understand how microbial communities perform complex functions and alter them for therapeutic or environmental effects. However, it is not yet possible to control the availability of those metabolites produced by some members of the community that are required by others. Here, we report the development of a metabolite 'quenching' strategy that disrupts a specific metabolic interaction involving corrinoids, the vitamin B

Indexed as

corrinoidscross-feedingmicrobial ecologynutritional immunityvitamin B12

Identifiers

PMID41509481
PMCPMC12776380

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.