Evidence map›Paper›PMID 41509473›Full record

ArticlebioRxiv : the preprint server for biology2025

Structural and functional evidence for ephaptic control of Purkinje cell spike timing by networks of molecular layer interneurons.

Aliya Norton, Elizabeth P Lackey, Sevgi Öztürk, Cole S Gaynor, Sean Ediger, Wei-Chung Allen Lee, Court A Hull, Wade G Regehr

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aliya NortonDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Elizabeth P LackeyDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Sevgi ÖztürkDepartment of Neurobiology, Duke University Medical School, Durham, NC, USA.
Cole S GaynorDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Sean EdigerDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Wei-Chung Allen LeeDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Court A HullDepartment of Neurobiology, Duke University Medical School, Durham, NC, USA.ORCID 0000-0002-0360-8367
Wade G RegehrDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3485-8094

Funding

Mechanisms and Functions of Synapses and CircuitsR35NS097284 · NINDS · HARVARD MEDICAL SCHOOL · PI REGEHR, WADE G · 2017 to 2024
$7.5M
Comprehensive and multi-resolution mapping of cell morphology and wiring through X-ray holographic nano-tomographyRF1MH128949 · NIMH · HARVARD MEDICAL SCHOOL · PI JOITA PACUREANU, ALEXANDRA TEODORA, LEE, WEI-CHUNG ALLEN · 2021 to 2021
$1.9M
Cerebellar circuits for reward-based learningR01NS128054 · NINDS · DUKE UNIVERSITY · PI COURT A HULL · 2022 to 2026
$1.9M
Cerebellar network mapping with a high-throughput TEM platformRF1MH114047 · NIMH · HARVARD MEDICAL SCHOOL · PI LEE, WEI-CHUNG ALLEN · 2017 to 2017
$1.3M
The role of cell-type specific circuits for inhibition and disinhibition in cerebellar learning and behaviorR01NS141997 · NINDS · DUKE UNIVERSITY · PI COURT A HULL · 2025 to 2026
$598k
Novel EM technologies for imaging neural network anatomyR21NS085320 · NINDS · HARVARD MEDICAL SCHOOL · PI LEE, WEI-CHUNG ALLEN · 2013 to 2014
$430k
Circuit Specializations of Cerebellar Molecular Layer InterneuronsF32NS133036 · NINDS · HARVARD MEDICAL SCHOOL · PI LACKEY, ELIZABETH · 2023 to 2025
$202k
NIMH NIH HHS RF1 MH114047NIMH NIH HHS RF1 MH128949NINDS NIH HHS F32 NS133036NINDS NIH HHS R01 NS128054NINDS NIH HHS R01 NS141997NINDS NIH HHS R21 NS085320NINDS NIH HHS R35 NS097284
6 · The paper itself

Abstract

Axon collaterals of type 1 molecular layer interneurons (MLI1s) contribute to pinceaux that engulf the initial segments of Purkinje cell (PC) axons and generate extracellular signals that ephaptically inhibit PCs. Here we show that a remarkably large number of MLI1s (~50) contribute to each pinceau, and that this allows networks of synchronously firing MLI1s to use ephaptic signals to control the precise timing of PC firing

Identifiers

PMID41509473
PMCPMC12776251

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.