Evidence map›Paper›PMID 41509448›Full record

ArticlebioRxiv : the preprint server for biology2025

UC Irvine's Brain Initiative Cell Atlas Network (BICAN) Brain Procurement Program for the Center for Multiomic Human Brain Cell Atlas Project.

Jillian V Berry, Bryan M Tran, Ginny Wu, Zhiqun Tan, Elizabeth Mendoza, Miyoung Kim, Zeynep Arat, Payton Sho Huai Lin, Lorena Valenzuela, Todd C Holmes and 39 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

49 authors.

Jillian V BerryDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Bryan M TranDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Ginny WuDepartment of Anatomy and Neurobiology, University of California, Irvine.
Zhiqun TanDepartment of Anatomy and Neurobiology, University of California, Irvine.
Elizabeth MendozaDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Miyoung KimDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Zeynep AratDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Payton Sho Huai LinDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Lorena ValenzuelaDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Todd C HolmesDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Anna VirovkaDepartment of Neurobiology and Behavior, University of California, Irvine.
Melina ThaxtonDepartment of Health Science Administration Neuroscience Institute, Children's Hospital of Orange County.
Matthew NguyenDepartment of Neurology, Children's Hospital of Orange County.
Sabrina SteinDepartment of Psychiatric and Human Behavior, University of California, Irvine.
Victoria Raha SigaroudiDepartment of Internal Medicine, University of California, Irvine.
Alexis De La RosaDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Brianna GawronskiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine.
Justine SilvaDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Lourdes GonzalezInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine.
Sierra WrightDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Kevin WoodInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine.
Gabriel K HuiDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Darren AnousayaDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Vishwaas Reddy GangeddulaDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Noah GamaDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Jasmine GamaDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Thomas GrossDepartment of Neurobiology and Behavior, University of California, Irvine.
Blynn BunneyDepartment of Psychiatric and Human Behavior, University of California, Irvine.
Richard SteinDepartment of Psychiatric and Human Behavior, University of California, Irvine.
Pedro Adolfo SequeiraDepartment of Psychiatric and Human Behavior, University of California, Irvine.
Firoza MamdaniDepartment of Psychiatric and Human Behavior, University of California, Irvine.
Preston CartagenaDepartment of Psychiatric and Human Behavior, University of California, Irvine.
William E BunneyDepartment of Psychiatric and Human Behavior, University of California, Irvine.
Jerry LouDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Hannah Lui ParkDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Amanda WilsonWilled Body Program, University of California, Irvine.
H Mark BrooksWilled Body Program, University of California, Irvine.
Virginia AllhusenDepartment of Pediatric Critical Care, Children's Hospital of Orange County.
John CrawfordDepartment of Pediatrics, University of California, Irvine.
Jason M KnightDepartment of Pediatric Critical Care, Children's Hospital of Orange County.
Bing RenNew York Genome Center, New York.
Joe EckerSalk Institute for Biological Studies, La Jolla, CA.
M Margarita BehrensSalk Institute for Biological Studies, La Jolla, CA.
C Dirk KeeneDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA.
Craig StarkDepartment of Neurobiology and Behavior, University of California, Irvine.
Elizabeth HeadDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
William YongDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Edwin MonukiDepartment of Pathology and Laboratory Medicine, University of California, Irvine.
Xiangmin XuDepartment of Anatomy and Neurobiology, University of California, Irvine.ORCID 0000-0002-5828-1533

Funding

Center for Multiomic Human Brain Cell AtlasUM1MH130994 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI MARIA MARGARITA BEHRENS, Joseph R Ecker · 2022 to 2026
$92.4M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0M
NIA NIH HHS P30 AG066509NIMH NIH HHS UM1 MH130994
6 · The paper itself

Abstract

High-quality neurotypical postmortem human brain tissue is essential but difficult to obtain for constructing comprehensive human brain cell atlases. Here we describe the establishment of UC Irvine's Brain Procurement Program, a coordinated initiative to collect and process neurotypical donor brains for multiomic mapping studies within the NIH BRAIN Initiative Cell Atlas Network (BICAN) consortium. Through partnerships with the Orange County Coroner's Office, the UC Irvine Willed Body Program, UCI Medical Center, and the Children's Hospital of Orange County, we have developed standardized workflows encompassing donor identification, postmortem brain recovery and processing, region-of-interest dissection, neurotypical donor selection, and data management. Our experience demonstrates the feasibility of a community-based, multi-institutional procurement framework while highlighting challenges in recruiting neurotypical donors and ensuring demographic representation reflective of Southern California. We further identify opportunities to strengthen outreach and donation pathways. This program provides a scalable model for advancing population-reflective, high-quality human brain cell atlas efforts.

Indexed as

BICANbrain collection and processingbrain donationhuman brain bankingneurotypicalpopulation-reflective representation

Identifiers

PMID41509448
PMCPMC12776169

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.