Evidence map›Paper›PMID 41509430›Full record

ArticlebioRxiv : the preprint server for biology2026

A non-canonical role of

Alexander G Foote, Le Xu, Jamie Verheyden, Belle Pan, Nikita Katoch, Xin Sun

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander G FooteDepartment of Pediatrics, University of California, San Diego.ORCID 0000-0002-3676-4091
Le XuDepartment of Pediatrics, University of California, San Diego.
Jamie VerheydenDepartment of Pediatrics, University of California, San Diego.
Belle PanDepartment of Pediatrics, University of California, San Diego.
Nikita KatochDepartment of Pediatrics, University of California, San Diego.
Xin SunDepartment of Pediatrics, University of California, San Diego.ORCID 0000-0003-4616-0088

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Dissecting the Interoception Circuit that Controls Airway ConstrictionR01AT011676 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUN, XIN · 2021 to 2025
$3.8M
Balancing Airway Progenitor versus Progeny: a Pathway from MitochondriaR01HL160019 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUN, XIN · 2021 to 2024
$2.1M
Neuroimmune interactions for laryngeal sensorimotor neuropathy in postviral influenza infectionF32DC021634 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FOOTE, ALEXANDER G · 2023 to 2025
$221k
NCCIH NIH HHS R01 AT011676NHLBI NIH HHS R01 HL160019NIDCD NIH HHS F32 DC021634NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

The upper respiratory epithelium is a specialized barrier that integrates immune surveillance with the biomechanical requirements of the laryngotracheal axis. Despite the clinical prevalence of persistent airway dysfunction following viral infection, the region-specific mechanisms governing laryngotracheal injury and repair remain poorly defined. Using integrated mouse models, imaging, and single-cell transcriptomics, we dissected IAV-induced injury in the upper respiratory tract. We found that infection displays regionally restricted tropism to subglottic and tracheal pseudostratified epithelia, targeting ciliated, secretory, neuroendocrine, and basal cells. Rapid viral clearance was accompanied by acute neutrophil infiltration and the emergence of a previously unrecognized intraepithelial CD8

Identifiers

PMID41509430
PMCPMC12776151

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.