Evidence map›Paper›PMID 41509415›Full record

ArticlebioRxiv : the preprint server for biology2025

Same class, different activity: Delamanid and pretomanid have comparable bactericidal activity but pretomanid potently inhibits

Matthew J Reichlen, Emmanuel Musisi, Samuel T Tabor, Holly Nielsen, Ashley M Gerwing, Firat Kaya, Matthew Zimmerman, Martin I Voskuil, Gregory T Robertson, Nicholas D Walter

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matthew J ReichlenDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus; Aurora, Colorado, USA.
Emmanuel MusisiConsortium for Applied Microbial Metrics; Aurora, CO, USA.
Samuel T TaborConsortium for Applied Microbial Metrics; Aurora, CO, USA.
Holly NielsenConsortium for Applied Microbial Metrics; Aurora, CO, USA.
Ashley M GerwingMycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University; Fort Collins, CO, USA.
Firat KayaCenter for Discovery and Innovation, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA.
Matthew ZimmermanCenter for Discovery and Innovation, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA.
Martin I VoskuilDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus; Aurora, Colorado, USA.
Gregory T RobertsonConsortium for Applied Microbial Metrics; Aurora, CO, USA.
Nicholas D WalterConsortium for Applied Microbial Metrics; Aurora, CO, USA.

Funding

Preclinical Design and Clinical Translation of TB Regimens (PReDicTR) ConsortiumUM1AI179699 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kelly E. Dooley, ERIC L NUERMBERGER · 2024 to 2026
$22.2M
BLRD VA I01 BX004527NIAID NIH HHS UM1 AI179699
6 · The paper itself

Abstract

Background: The nitroimidazoles delamanid and pretomanid play an important role in contemporary tuberculosis treatment. It is unclear whether delamanid and pretomanid have meaningfully different activity since both reduce Methods: Using Results: Conclusions: We found that delamanid and pretomanid have similar bactericidal activity but pretomanid has superior RS ratio activity. Meaningful differences between drugs within the same class were not captured by conventional CFU-based pharmacodynamics, supporting the value of measuring orthogonal drug effects such as the RS ratio.

Indexed as

antibioticbactericidal activityconcentration responsedose rangingpharmacodynamicsterilizing activitytuberculosis

Identifiers

PMID41509415
PMCPMC12776329

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.