Evidence map›Paper›PMID 41509395›Full record

ArticlebioRxiv : the preprint server for biology2026

A prelimbic molecular clock of protein synthesis for memory persistence.

J Iqbal, S Kim, S Lawal, A Shah, L Punepalle, H Sanghvi, A Gallagher, A Wilson, B Xu, P Shrestha

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

J IqbalDepartment of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY 11794.
S KimDepartment of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY 11794.
S LawalDepartment of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY 11794.
A ShahDepartment of Computer Science, Stony Brook University, Stony Brook, NY 11794.
L PunepalleDepartment of Computer Science, Stony Brook University, Stony Brook, NY 11794.
H SanghviDepartment of Computer Science, Stony Brook University, Stony Brook, NY 11794.
A GallagherDepartment of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY 11794.
A WilsonDepartment of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY 11794.
B XuDepartment of Neuroscience, UF Scripps Biomedical Research, Jupiter, FL 33458.ORCID 0000-0002-2416-6633
P ShresthaDepartment of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY 11794.ORCID 0000-0002-4677-0225

Funding

Molecular and cellular basis for autism spectrum disorders caused by exacerbated translationR01MH125187 · NIMH · UNIVERSITY OF FLORIDA · PI RUMBAUGH, GAVIN R, XU, BAOJI · 2020 to 2024
$2.7M
Prefrontal pathway-specific modulation of protein synthesis in emotional memoriesR01MH132795 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI Prerana Shrestha · 2024 to 2026
$1.7M
Scholars in BioMedical Sciences (SBMS) Training ProgramT32GM148331 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Styliani-Anna (Stella) E Tsirka · 2024 to 2026
$695k
NIGMS NIH HHS T32 GM148331NIMH NIH HHS R01 MH125187NIMH NIH HHS R01 MH132795
6 · The paper itself

Abstract

Emotionally salient associative memories can endure for long periods, yet the mechanisms that determine their long-term stability remain unclear. Here we show that the prelimbic (PL) cortex integrates temporally structured translational programs to control both the consolidation and reconsolidation of cued threat memories. Using Pavlovian threat conditioning with

Identifiers

PMID41509395
PMCPMC12776337

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.