Evidence map›Paper›PMID 41509376›Full record

ArticlebioRxiv : the preprint server for biology2026

Functional Evaluation of

Ying Wu, Xiaojing Sun, Joseph S Reddy, Pooja P Advani, Nicholas J Boddicker, James R Cerhan, Hector R Villarraga, Samuel J Asirvatham, Ru-Xing Wang, Hon-Chi Lee and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ying WuThe Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Xiaojing SunThe Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Joseph S ReddyThe Department of Quantitative Health Sciences, Mayo Clinic, Florida, 4500 San Pablo Rd S. Jacksonville, Florida, FL 32224, USA.ORCID 0000-0002-1783-4453
Pooja P AdvaniThe Department of Hematology and Oncology, Mayo Clinic, Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224, USA.
Nicholas J BoddickerDivision of Computational Biology, Mayo Clinic, Rochester, MN, USA.
James R CerhanDivision of Epidemiology, Mayo Clinic, Rochester, MN, USA.
Hector R VillarragaThe Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Samuel J AsirvathamThe Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Ru-Xing WangThe Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299 Qingyang Road, Wuxi 214023, Jiangsu Province, P. R. China.
Hon-Chi LeeThe Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Nadine NortonThe Department of Cancer Biology, Mayo Clinic, Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224, USA.
Tong LuThe Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Funding

The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI HOUTMAN, JON C.D. · 2002 to 2021
$45.7M
The Lymphoma Epidemiology of Outcomes (LEO) Cohort Study (Supplement)U01CA195568 · NCI · MAYO CLINIC ROCHESTER · PI CERHAN, JAMES R, FLOWERS, CHRISTOPHER R · 2015 to 2025
$22.1M
Sorbs2 targeting and BK channel regulation in the coronary artery of patients with type 1 diabetesR01HL161821 · NHLBI · MAYO CLINIC ROCHESTER · PI Tong Lu · 2022 to 2026
$2.7M
Individualized medicine to predict and prevent chemotherapy-related heart failureR01HL169268 · NHLBI · MAYO CLINIC JACKSONVILLE · PI NORTON, NADINE · 2023 to 2025
$1.9M
NCI NIH HHS P50 CA097274NCI NIH HHS U01 CA195568NHLBI NIH HHS R01 HL161821NHLBI NIH HHS R01 HL169268
6 · The paper itself

Abstract

Gain-of-function mutations in the transient receptor potential 6 (TRPC6) channel have recently been recognized as risk factors for both doxorubicin (DOX)-induced cardiomyopathy. Functional evaluation of

Indexed as

1-oleoyl-2-acetyl-sn-glyceroldoxorubicinIn-silico analysispatch-clamp recodingTRPC6 missense variant

Identifiers

PMID41509376
PMCPMC12776546

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.