Evidence map›Paper›PMID 41509374›Full record

ArticlebioRxiv : the preprint server for biology2025

Molecular insights into Profilin1-dependent regulation of cellular phosphatidylinositol-(4,5)-bisphosphate.

Andrew Orenberg, Michael Chirumbolo, Ian Eder, Jia-Jun Liu, Silvia Liu, David Gau, Yubo Tang, Klemens Rottner, Jianhua Luo, Gerald Hammond and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Andrew OrenbergBioengineering, University of Pittsburgh.
Michael ChirumboloCell Biology, University of Pittsburgh.
Ian EderCell Biology, University of Pittsburgh.
Jia-Jun LiuPathology, University of Pittsburgh.
Silvia LiuPathology, University of Pittsburgh.
David GauPathology, University of Pittsburgh.
Yubo TangInstitute of Zoology, Technical University of Braunschweig.
Klemens RottnerInstitute of Zoology, Technical University of Braunschweig.ORCID 0000-0003-4244-4198
Jianhua LuoPathology, University of Pittsburgh.
Gerald HammondCell Biology, University of Pittsburgh.ORCID 0000-0002-6660-3272
Partha RoyBioengineering, University of Pittsburgh.

Funding

Cardiovascular Bioengineering Training ProgramT32HL076124 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANJEEV G SHROFF · 2005 to 2026
$7.0M
Profilin biology in breast cancerR01CA248873 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROY, PARTHA · 2021 to 2025
$1.8M
Transcriptional Regulation of Dormancy and Emergence in Breast CancerR01CA271095 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PARTHA ROY · 2023 to 2026
$1.5M
Discovery of Cell-based Chemical Probes Targeting Aberrant Angiogenesis in the EyeR21EY032632 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HURYN, DONNA M, KOES, DAVID RYAN · 2022 to 2023
$426k
NCI NIH HHS R01 CA248873NCI NIH HHS R01 CA271095NEI NIH HHS R21 EY032632NHLBI NIH HHS T32 HL076124
6 · The paper itself

Abstract

Phosphatidylinositol (4,5)-bisphosphate (PIP

Indexed as

diacylglycerolhydrolysisphospholipasePIP2Profilin1

Identifiers

PMID41509374
PMCPMC12776038

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.