Evidence map›Paper›PMID 41509373›Full record

ArticlebioRxiv : the preprint server for biology2025

A single catalytic domain residue regulates the substrate specificity of a mucin-type O-glycosyltransferase in salivary gland function.

Pranav Kumar, Navid Tahan Zadeh, Zulfeqhar A Syed, Hayley M Reynolds, Duy T Tran, Liping Zhang, Kelly G Ten Hagen, Nadine L Samara

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pranav KumarStructural Biochemistry Unit, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, 20892, USA.ORCID 0000-0002-4659-7725
Navid Tahan ZadehDevelopmental Glycobiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, 20892, USA.ORCID 0009-0009-5576-6277
Zulfeqhar A SyedElectron Microscopy Core, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, 20892, USA.ORCID 0000-0002-5825-9782
Hayley M ReynoldsUniversity of Utah, School of Medicine, Salt Lake City, UT, 84132, USA.ORCID 0000-0002-3077-5603
Duy T TranNational Eye Institute, NIH, Bethesda, MD, 20892, USA.
Liping ZhangDevelopmental Glycobiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, 20892, USA.ORCID 0000-0001-8637-4975
Kelly G Ten HagenDevelopmental Glycobiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, 20892, USA.ORCID 0000-0002-2057-8120
Nadine L SamaraStructural Biochemistry Unit, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, 20892, USA.ORCID 0000-0001-7152-2939

Funding

Role of O-glycosylation in Animal DevelopmentZIADE000713 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI TEN HAGEN, KELLY G · 2009 to 2025
$30.6M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Structural and functional studies of polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts)ZIADE000754 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI SAMARA, NADINE · 2020 to 2025
$4.0M
Intramural NIH HHS ZIA DE000713Intramural NIH HHS ZIA DE000754NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Human GalNAc-T1 is a ubiquitously expressed mucin-type O-glycosyltransferase that modulates various biological pathways, including immunity, extracellular matrix formation, and salivary gland development and function. However, substrates of GalNAc-T1 are mostly unknown and the mechanistic details of regulation are not well characterized. Here, we investigate the role of the

Identifiers

PMID41509373
PMCPMC12776162

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.