In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
27 authors.
Johannes TüchlerCenter for Cancer Research, Medical University of Vienna, Vienna, Austria.
Andrea EspositoDepartment of Physics, University of Naples Federico II and National Institute of Nuclear Physics, Naples, Italy.
Mattia ConteDepartment of Physics, University of Naples Federico II and National Institute of Nuclear Physics, Naples, Italy.ORCID 0000-0002-6670-9800 Ekapaksi WisnumurtiDepartment for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.
Julie GamartDepartment for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.
Raquel Rouco GarciaDepartment of Genetic Medicine and Development and iGE3, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-0657-0704 Brandon J MannionEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.ORCID 0000-0002-1149-3790 Jennifer A AkiyamaEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.ORCID 0000-0002-0667-9355 Harry WalkerHerman B Wells Center for Pediatric Research, Departments of Pediatrics, Anatomy and Medical and Molecular Genetics, Indiana Medical School, Indianapolis, IN 46202, USA.
Ali Hashemi GheinaniDepartment for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.ORCID 0000-0002-9625-6259 Beth A FirulliHerman B Wells Center for Pediatric Research, Departments of Pediatrics, Anatomy and Medical and Molecular Genetics, Indiana Medical School, Indianapolis, IN 46202, USA.
Gretel NusspaumerCentro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide Junta de Andalucía, Seville, Spain.ORCID 0000-0002-3870-0964 Anthony B FirulliHerman B Wells Center for Pediatric Research, Departments of Pediatrics, Anatomy and Medical and Molecular Genetics, Indiana Medical School, Indianapolis, IN 46202, USA.ORCID 0000-0001-6687-8949 Guillaume AndreyDepartment of Genetic Medicine and Development and iGE3, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-0911-4907 Axel ViselEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.ORCID 0000-0002-4130-7784 Javier Lopez-RiosCentro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide Junta de Andalucía, Seville, Spain.ORCID 0000-0001-6731-3798 Mario NicodemiDepartment of Physics, University of Naples Federico II and National Institute of Nuclear Physics, Naples, Italy.ORCID 0000-0002-8416-6416 Funding
Generation of an In Vivo Human Genome Transcriptional Enhancer DatasetR01HG003988 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Len Alexander Pennacchio · 2006 to 2026
$24.1MEvaluating the Impact of Mutations in Distant-Acting Enhancers in Structural Birth DefectsR01HD114353 · NICHD · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Len Alexander Pennacchio, Axel Visel · 2023 to 2026
$3.3MIn vivo Characterization of Regulatory Variant Pathogenicity in Congenital Heart DiseaseR01HL162304 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PENNACCHIO, LEN ALEXANDER, VISEL, AXEL · 2022 to 2025
$3.0MNHGRI NIH HHS R01 HG003988NHLBI NIH HHS R01 HL162304NICHD NIH HHS R01 HD114353
6 · The paper itselfAbstract
Congenital heart disease (CHD), the most common human birth defect, often results from disruptions in gene regulatory networks (GRNs) that control cardiac lineage specification and cell type identity during heart development. A conserved core set of cardiac transcription factors (TFs) orchestrates these processes through combinatorial interactions that are cell type-specific and tightly regulated across space and time. However, the genomic enhancer architecture that integrates upstream effectors to establish precise cardiac TF dosage and downstream transcriptional output remains largely unresolved. Here, we assessed the functional necessity of five developmental heart enhancer modules previously linked to the regulation of
Identifiers
PMID41509364
PMCPMC12776112
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