Evidence map›Paper›PMID 41509363›Full record

ArticlebioRxiv : the preprint server for biology2025

Regulation of STING activation by phosphoinositide and cholesterol.

Jie Li, Jay Xiaojun Tan, Zhijian J Chen, Xuewu Zhang, Xiao-Chen Bai

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jie LiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jay Xiaojun TanDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.ORCID 0000-0003-3300-2240
Zhijian J ChenDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Xuewu ZhangDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Xiao-Chen BaiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
Novel regulatory mechanisms and agonists of STINGR01CA273595 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Xiaochen Bai, CHUO CHEN · 2023 to 2026
$2.7M
Biochemical Dissection of the RIG-I Antiviral PathwayR01AI093967 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, ZHIJIAN J · 2011 to 2015
$2.0M
Lysosomal quality control through lipid remodelingR35GM150506 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Xiaojun Tan · 2023 to 2026
$1.8M
Novel endogenous and engineered activators of STING: from mechanisms to cancer therapyR01CA299257 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Xiaochen Bai, Zhijian J Chen · 2025 to 2026
$1.3M
NCI NIH HHS R01 CA273595NCI NIH HHS R01 CA299257NIAID NIH HHS R01 AI093967NIGMS NIH HHS R35 GM150506NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

Stimulator of interferon genes (STING) is an essential adaptor in the cytosolic DNA sensing innate immune pathway. STING is activated by cyclic-GMP-AMP (cGAMP) produced by the DNA sensor cGAMP synthase (cGAS). cGAMP-induced high-order oligomerization and translocation of STING from the endoplasmic reticulum to Golgi and post-Golgi vesicles are critical for STING activation. Recent studies have shown that phosphatidylinositol phosphates (PIPs) and cholesterol also play important roles in STING activation, but the underlying mechanisms remain unclear. Here, we demonstrate that cGAMP-induced high-order oligomerization of STING is enhanced strongly by PI(3,5)P

Identifiers

PMID41509363
PMCPMC12776314

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.