Evidence map›Paper›PMID 41509356›Full record

ArticlebioRxiv : the preprint server for biology2025

Differential retinoic acid responses across testicular development

Brad C Hansen, Sarah A Hatem, Lucas A Huang, John K Amory, Elaine M Faustman, Edward J Kelly

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brad C HansenDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, U.S.A.ORCID 0000-0003-1524-0878
Sarah A HatemDepartment of Pharmaceutics, University of Washington, Seattle, Washington, U.S.A.
Lucas A HuangDepartment of Pharmaceutics, University of Washington, Seattle, Washington, U.S.A.
John K AmoryDepartment of Medicine, University of Washington, Seattle, Washington, U.S.A.
Elaine M FaustmanDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, U.S.A.
Edward J KellyDepartment of Pharmaceutics, University of Washington, Seattle, Washington, U.S.A.ORCID 0000-0002-6534-9313

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
Environmetal Pathology/Toxicology Training ProgramT32ES007032 · NIEHS · UNIVERSITY OF WASHINGTON · PI FAUSTMAN, ELAINE M, ROSENFELD, MICHAEL E · 1985 to 2023
$10.7M
NIEHS NIH HHS P30 ES007033NIEHS NIH HHS T32 ES007032
6 · The paper itself

Abstract

Spermatogonial differentiation is controlled by distinct spatial and temporal activities of metabolizing enzymes and signaling molecule formation. In vitro models are reductionist ways to examine the interactions between Sertoli cells and spermatogonial stem cells, which may be therapeutic targets for infertility that cause non-obstructive azoospermia, due to either Sertoli-cell only syndrome, hypospermatogenesis or maturation arrest. Here, we find that nanomolar doses of isotretinoin are sufficient to drive

Indexed as

cell cultureDevelopmentin vitroReproductionRetinoidSpermatogoniaTestis

Identifiers

PMID41509356
PMCPMC12776405

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.