Evidence map›Paper›PMID 41509341›Full record

ArticlebioRxiv : the preprint server for biology2025

Dysfunctional memory B cell responses to the protective repeat region of the

Courtney E McDougal, Catherine G Mkindi, Lauren B Rodda, Caroline V Lucarelli, Mark D Langowski, Neil P King, Said Jongo, Claudia Daubenberger, Marion Pepper

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Courtney E McDougalDepartment of Immunology, University of Washington School of Medicine, Seattle, WA 98109.ORCID 0000-0003-1607-5931
Catherine G MkindiIfakara Health Institute, Bagamoyo, Tanzania.
Lauren B RoddaDepartment of Immunology, University of Washington School of Medicine, Seattle, WA 98109.
Caroline V LucarelliDepartment of Immunology, University of Washington School of Medicine, Seattle, WA 98109.
Mark D LangowskiInstitute for Protein Design, University of Washington, Seattle, WA 98109.
Neil P KingInstitute for Protein Design, University of Washington, Seattle, WA 98109.
Said JongoIfakara Health Institute, Bagamoyo, Tanzania.
Claudia DaubenbergerSwiss Tropical Public Health Institute, Basel, Switzerland.
Marion PepperDepartment of Immunology, University of Washington School of Medicine, Seattle, WA 98109.ORCID 0000-0001-7278-0147

Funding

Inducing durable, protective immune memory against malariaU01AI142001 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI KAPPE, STEFAN HI, PEPPER, MARION · 2019 to 2023
$5.5M
Acquisition of BD FACSymphony A3 Lite Flow CytometerS10OD024979 · OD · UNIVERSITY OF WASHINGTON · PI BLACK, MICHELE C · 2020 to 2020
$344k
Understanding and overcoming Plasmodium-specific immune evasion mechanismsF32AI178963 · NIAID · UNIVERSITY OF WASHINGTON · PI MCDOUGAL, COURTNEY · 2024 to 2025
$157k
Gates Foundation INV-009411Gates Foundation INV-010680NIAID NIH HHS F32 AI178963NIAID NIH HHS U01 AI142001NIH HHS S10 OD024979
6 · The paper itself

Abstract

Malaria vaccines provide waning protection from disease that is correlated with the production of antibodies to the repeat region of the liver-stage circumsporozoite protein (CSP). CSP-based vaccines display limited durability in malaria-naïve individuals yet are even less effective in malaria-experienced individuals, suggesting the generation of non-optimal humoral immunity in response to both infection and vaccination. To address this hypothesis, we performed a cross-species, comprehensive analysis of B cell responses to CSP after

Identifiers

PMID41509341
PMCPMC12776172

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.