ArticlebioRxiv : the preprint server for biology2025
Adjacent Dorsolateral Prefrontal Cortex (DLPFC) Regions Participate in Distinct Large-Scale Networks Differentially Recruited for Social and Cognitive Control Functions.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Human prefrontal cortex (PFC) is heterogenous. In monkeys, side-by-side PFC regions, including within dorsolateral PFC (DLPFC), show distinct long-range anatomical projection profiles, raising the possibility that adjacent regions might specialize as a consequence of the distributed networks in which they are embedded. Consistent with this possibility, recent findings in humans provide evidence for PFC regions domain-specialized for scene (spatial) processing and language processing that are adjacent to distinct domain-flexible regions responding to traditional cognitive control demands. Here we tested functional specialization of PFC regions linked to another domain-specialized network recruited by certain forms of social processing (theory-of-mind, ToM, tasks). Using within-individual precision neuroimaging approaches, side-by-side DLPFC regions embedded within parallel distributed networks were identified within the idiosyncratic anatomy of each individual (
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