ArticlebioRxiv : the preprint server for biology2025
Non-uniform chromosomal SNP density biases sites of meiotic crossovers in
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Here we localize a genetic suppressor that enhances the reduced locomotor activity phenotype of flies lacking brain dopamine. We utilized a non-bulked segregant analysis using whole genome sequencing (WGS), mapping the trait to a roughly 3.5 mega-base (Mb) region of the X-chromosome. However, this mapping yielded ~5-fold lower resolution than anticipated, due to an uneven distribution of Single Nucleotide Polymorphisms (SNPs) between the X-chromosomes of the two recombining lines. This uneven SNP distribution was associated with recombination events biased towards regions of low SNP density, and away from the more SNP dense regions associating with the activity phenotype. We find that nearly perfect mapping of X-chromosome visible markers occurs only in historical data from a time before the establishment of discrete genetic background strains. This suggests that genetic uniformity in early
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