Evidence map›Paper›PMID 41509305›Full record

ArticlebioRxiv : the preprint server for biology2025

Molecular Mechanisms of Priming Innate Immunity by Small Extracellular Vesicles Released during Infection with Gram-negative Bacteria.

Adam Fleming, Heather Hobbs, Graham Matulis, Weidong Zhou, Valerie Calvert, Hunter Mason, Samson Omole, Shivam A Gaikwad, Cameron C Ellis, Emanuel F Petricoin and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Adam FlemingSchool of Systems Biology, George Mason University, Manassas, VA, USA.
Heather HobbsSchool of Systems Biology, George Mason University, Manassas, VA, USA.
Graham MatulisSchool of Systems Biology, George Mason University, Manassas, VA, USA.
Weidong ZhouCenter for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA.
Valerie CalvertCenter for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA.
Hunter MasonSchool of Systems Biology, George Mason University, Manassas, VA, USA.
Samson OmoleSchool of Systems Biology, George Mason University, Manassas, VA, USA.
Shivam A GaikwadSchool of Systems Biology, George Mason University, Manassas, VA, USA.
Cameron C EllisBorder Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.
Emanuel F PetricoinSchool of Systems Biology, George Mason University, Manassas, VA, USA.
Igor C AlmeidaBorder Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.
Ramin M HakamiSchool of Systems Biology, George Mason University, Manassas, VA, USA.

Funding

Infection Site Targeted Antitoxin Antibody (ISTAb) against Bacillus anthracisR42AI122666 · NIAID · INTEGRATED BIOTHERAPEUTICS, INC. · PI ADHIKARI, RAJAN P, HAKAMI, RAMIN M. · 2019 to 2021
$3.0M
Infection Site Targeted Antitoxin Antibody (ISTAb) against Bacillus anthracisR41AI122666 · NIAID · INTEGRATED BIOTHERAPEUTICS, INC. · PI ADHIKARI, RAJAN P, HAKAMI, RAMIN M. · 2017 to 2018
$595k
NIAID NIH HHS R41 AI122666NIAID NIH HHS R42 AI122666
6 · The paper itself

Abstract

Much still remains to understand about the underlying molecular mechanisms by which the trafficking of small extracellular vesicles (sEVs) modulates innate immune responses during infection with pathogenic Gram-negative bacteria. To address this significant gap in knowledge, we used two infection models to investigate innate immune regulation by the sEVs released from cells infected with either

Indexed as

Bacterial ClearanceBacterial SpreadBurkholderia thailandensisGram-negative PathogensIL-6Innate Immune ResponseMonocytesp38Small extracellular vesiclesYersinia pestis

Identifiers

PMID41509305
PMCPMC12776559

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.