Evidence map›Paper›PMID 41509304›Full record

ArticlebioRxiv : the preprint server for biology2026

Genome writing and Targeted Delivery of the

Noor Chalhoub, Arushi Varshney, Weimin Zhang, Skyler Uhl, Jon M Laurent, Colleen McLoughlin, Hannah Ashe, Xingrui Mou, Nathan Dale, Kiran Ramnarine and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Noor ChalhoubInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA 10016.
Arushi VarshneyGilbert S. Omenn Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA 48109.ORCID 0000-0001-9177-9707
Weimin ZhangInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA 10016.
Skyler UhlInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA 10016.
Jon M LaurentInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA 10016.ORCID 0000-0001-6583-4741
Colleen McLoughlinInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA 10016.
Hannah AsheInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA 10016.
Xingrui MouThe Jackson Laboratory-New York Stem Cell Foundation Research Institute, New York, NY, USA.
Nathan DaleThe Jackson Laboratory-New York Stem Cell Foundation Research Institute, New York, NY, USA.
Kiran RamnarineThe Jackson Laboratory-New York Stem Cell Foundation Research Institute, New York, NY, USA.
Daniel PaullThe Jackson Laboratory-New York Stem Cell Foundation Research Institute, New York, NY, USA.
Jordan GoldbergThe Jackson Laboratory-New York Stem Cell Foundation Research Institute, New York, NY, USA.
Matthew T MauranoInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA 10016.ORCID 0000-0002-2218-8628
Ran BroshInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA 10016.
David FenyöInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA 10016.
Filippo CiprianiThe Jackson Laboratory-New York Stem Cell Foundation Research Institute, New York, NY, USA.
Stephen C J ParkerGilbert S. Omenn Dept. of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA 48109.
Jef D BoekeInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA 10016.ORCID 0000-0001-5322-4946

Funding

Supplement for Center for Synthetic Regulatory Genomics: Building CACNA1C alleles associated with Neuropsychiatric DisordersRM1HG009491 · NHGRI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jef D BOEKE · 2018 to 2026
$20.9M
Bridging the gap between type 2 diabetes GWAS and therapeutic targetsUM1DK126185 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CLAUSSNITZER, MELINA C, GLOYN, ANNA LOUISE · 2020 to 2024
$9.5M
Training Program in Cell BiologyT32GM136542 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SMITH, SUSAN · 2020 to 2024
$3.0M
Context-specific and combinatorial genetic regulatory grammars in diabetesR01DK117960 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Stephen CJ Parker · 2018 to 2026
$2.8M
NHGRI NIH HHS RM1 HG009491NIDDK NIH HHS R01 DK117960NIDDK NIH HHS UM1 DK126185NIGMS NIH HHS T32 GM136542
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) identified over 600 loci containing single-nucleotide polymorphisms (SNPs) associated with type 2 diabetes (T2D), most of which reside in non-coding regions. Among the set of T2D SNPs, linking causal genome variants to disease risk experimentally has remained a challenge; however, advances in synthetic mammalian genome writing techniques now enable the delivery of multiple haplotypes to human induced pluripotent stem cells (hiPSCs) to create a series of isogenic cell lines that can be differentiated and phenotyped

Indexed as

genetic engineeringGWAS variantsNKX6-3/ANK1stem cellsType 2 diabetes

Identifiers

PMID41509304
PMCPMC12776320

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.