Evidence map›Paper›PMID 41509302›Full record

ArticlebioRxiv : the preprint server for biology2025

Rapid and repeated evolution of myosin copy number in threespine stickleback.

Alyssa M Yoxsimer, Rhea R Daugherty, Emily E Hare, Yingguang Frank Chan, Felicity C Jones, Garrett A Roberts Kingman, Emma G Offenberg, Timothy R Howes, Haili Zhang, Alex A Pollen and 16 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Alyssa M YoxsimerDepartment of Genetics, Stanford University School of Medicine, Stanford, CA USA.ORCID 0000-0002-1621-2898
Rhea R DaughertyDepartment of Genetics, Stanford University School of Medicine, Stanford, CA USA.
Emily E HareDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
Yingguang Frank ChanDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-6292-9681
Felicity C JonesDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-5027-1031
Garrett A Roberts KingmanDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-1910-3005
Emma G OffenbergDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
Timothy R HowesDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-0370-0200
Haili ZhangDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
Alex A PollenDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-3263-8634
Shannon D BradyDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
Kathleen T XieDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-3178-8959
Heidi I ChenDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1744-8461
Craig B LoweDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6838-1976
Eric H AuPresent address: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0001-5889-296X
Jane GrimwoodHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.ORCID 0000-0002-8356-8325
Jeremy SchmutzHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.ORCID 0000-0001-8062-9172
Richard M MyersHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.ORCID 0000-0001-9701-676X
Dolph SchluterBiodiversity Research Centre, University of British Columbia, Victoria, Canada.ORCID 0000-0003-1683-7836
David C HeinsDepartment of Ecology and Evolutionary Biology, Tulane University, New Orleans, LA, USA.ORCID 0000-0002-6175-8777
Miguel L ReyesDepartment of Biology, Clark University, Worcester, MA, USA.
John A BakerDepartment of Biology, Clark University, Worcester, MA, USA.
Bjarni JónssonAlthingi Parliament, Reykjavik, Iceland.
Thomas E ReimchenDepartment of Biology, University of Victoria, Victoria, Canada.
Michael A BellUniversity of California Museum of Paleontology, Berkeley, CA, USA.
David M KingsleyDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6401-6461

Funding

INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2M
Genomic Basis of Vertebrate DiversityP50HG002568 · NHGRI · STANFORD UNIVERSITY · PI KINGSLEY, DAVID M · 2002 to 2011
$29.2M
Dynamics of Contemporary Genomic Evolution in Replicate Threespine Stickleback PopulationsR01GM124330 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI VEERAMAH, KRISHNA R · 2017 to 2021
$1.6M
NHGRI NIH HHS P50 HG002568NHGRI NIH HHS T32 HG000044NIGMS NIH HHS R01 GM124330
6 · The paper itself

Abstract

Copy number variants at genomic loci evolve at a high rate, are linked to many different diseases, and play a role in adaptive evolution in humans and other organisms. Here we show that stickleback fish from freshwater environments have rapidly and repeatedly evolved an expanded number of copies of a gene family involved in muscle development,

Indexed as

adaptive evolutioncontemporary evolutioncopy number variationGasterosteus aculeatusmicrohomology-mediated break-induced replicationmyosin heavy chainnon-allelic homologous recombinationspecies pairssticklebacks

Identifiers

PMID41509302
PMCPMC12776057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.