Evidence map›Paper›PMID 41509301›Full record

ArticlebioRxiv : the preprint server for biology2025

Altered aperiodic EEG spectral power during speech perception task is associated with verbal communication in youths with Autism Spectrum Disorder.

Vardan Arutiunian, Megha Santhosh, Emily Neuhaus, Heather Borland, Raphael A Bernier, Susan Y Bookheimer, Mirella Dapretto, Abha R Gupta, Allison Jack, Shafali Jeste and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Vardan ArutiunianCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA.ORCID 0000-0001-9417-0913
Megha SanthoshCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA.
Emily NeuhausCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA.
Heather BorlandCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA.
Raphael A BernierDepartment of Psychiatry and Behavioral Science, University of Washington, Seattle, WA, USA.
Susan Y BookheimerCenter for Autism Research and Treatment, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Mirella DaprettoCenter for Autism Research and Treatment, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Abha R GuptaDepartment of Pediatrics, Yale School of Medicine, Yale University, New Haven, CT, USA.
Allison JackDepartment of Psychology, George Mason University, Fairfax, VA, USA.
Shafali JesteDepartment of Pediatrics and Neurology, USC Keck School of Medicine, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
James C McPartlandYale Child Study Center, Yale School of Medicine, Yale University, New Haven, CT, USA.
Adam NaplesYale Child Study Center, Yale School of Medicine, Yale University, New Haven, CT, USA.
John D Van HornSchool of Data Science, University of Virginia, Charlottesville, VA, USA.
Kevin A PelphreyDepartment of Neurology, School of Medicine, University of Virginia, Charlottesville, VA, USA.
Sara J WebbCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA.

Funding

Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI DOHERTY, DANIEL · 2014 to 2019
$7.9M
Parsing ASD Heterogeneity: Neuroendophenotypes of Social Attention and Sensory ResponsivityR01MH117982 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAPRETTO, MIRELLA, PELPHREY, KEVIN A · 2018 to 2023
$3.8M
NICHD NIH HHS U54 HD083091NIMH NIH HHS R01 MH117982
6 · The paper itself

Abstract

Most children with Autism Spectrum Disorder (ASD) have co-occurring language impairment, but its neural mechanisms are not well known. Excitation (E) / inhibition (I) imbalance is considered as a key neurobiological mechanism of ASD, and several electroencephalography (EEG)-based E/I balance metrics have been proposed in the previous studies. The goal of the present research was to focus on these metrics abstracted from the speech perception task to investigate their relation to language/communication in autistic youths. We used a high-density 128-channel EEG to register neural responses during speech perception task in the sex- and age-matched groups of youths with ASD (

Indexed as

Autism Spectrum Disorderexcitation / inhibition imbalancelanguage impairmentneural ‘noise’periodic and aperiodic EEGspeech perception

Identifiers

PMID41509301
PMCPMC12776406

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.