Evidence map›Paper›PMID 41509289›Full record

ArticlebioRxiv : the preprint server for biology2025

COPS5 is Essential for Sertoli Cell Function and Male Fertility in Mice.

Changmin Niu, Tao Li, Wei Li, Yi Tian Yap, Qian Huang, Lei Jiang, Opeyemi Dhikhirullahi, Ava Miciuda, Eva Faddoul, Shizheng Song and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Changmin NiuSchool of Nursing, Faculty of Medicine, Yangzhou University, Yangzhou, Jiangsu, China.ORCID 0000-0002-0918-3566
Tao LiDepartment of Physiology, Wayne State University, Detroit, MI, USA.
Wei LiDepartment of Physiology, Wayne State University, Detroit, MI, USA.
Yi Tian YapDepartment of Physiology, Wayne State University, Detroit, MI, USA.
Qian HuangDepartment of Physiology, Wayne State University, Detroit, MI, USA.
Lei JiangSchool of Medical Nurse and Health, Wuhan Business and Trade Vocational College, Wuhan, Hubei, China.
Opeyemi DhikhirullahiDepartment of Physiology, Wayne State University, Detroit, MI, USA.
Ava MiciudaDepartment of Physiology, Wayne State University, Detroit, MI, USA.
Eva FaddoulDepartment of Physiology, Wayne State University, Detroit, MI, USA.
Shizheng SongSchool of Medical Nurse and Health, Wuhan Business and Trade Vocational College, Wuhan, Hubei, China.
Michael D GriswoldSchool of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington, USA.
Zhibing ZhangDepartment of Physiology, Wayne State University, Detroit, MI, USA.ORCID 0000-0002-8615-4478

Funding

Hormonal Regulation Sertoli Cell MaturationR01HD010808 · NICHD · WASHINGTON STATE UNIVERSITY · PI MICHAEL D GRISWOLD · 1985 to 2026
$6.0M
Intraflagellar transport (IFT) and sperm formationR01HD105944 · NICHD · WAYNE STATE UNIVERSITY · PI Zhibing Zhang · 2022 to 2026
$2.4M
The mechanisms of MEIG1 complex in mammalian spermiogenesis and fertilizationR01HD114311 · NICHD · WAYNE STATE UNIVERSITY · PI Saher Sue Hammoud, Christopher V Kelly · 2024 to 2026
$1.9M
NICHD NIH HHS R01 HD010808NICHD NIH HHS R01 HD105944NICHD NIH HHS R01 HD114311
6 · The paper itself

Abstract

The COP9 signalosome subunit 5 (COPS5) is a multifunctional protein that regulates ubiquitin-dependent processes. Global knockout of

Indexed as

BTBcell polarityCOPS5infertilitySertoli cells

Identifiers

PMID41509289
PMCPMC12776080

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.