ArticlebioRxiv : the preprint server for biology2025
Juvenile reinstatement of TCF4 in Pitt-Hopkins syndrome model mice reveals a critical window for genetic intervention.
Lucas M James, Carlee A Friar, Siyuan Liang, Eric B Gao, Alain C Burette, Benjamin D Philpot
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
6 authors.
Lucas M JamesUNC Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, NC 27599, USA.
Carlee A FriarUNC Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, NC 27599, USA.
Siyuan LiangUNC Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, NC 27599, USA.
Eric B GaoUNC Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, NC 27599, USA.
Alain C BuretteUNC Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, NC 27599, USA.
Benjamin D PhilpotUNC Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, NC 27599, USA.ORCID 0000-0003-2746-9143 Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5MSmall Molecule Therapeutic Discovery for Angelman SyndromeR01NS131615 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jeffrey Aube, BENJAMIN D PHILPOT · 2023 to 2026
$2.3MBRAIN Viral Vector Services and Distribution CoreU24NS124025 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RITOLA, KIMBERLY · 2021 to 2025
$1.9MTCF4 in Pitt-Hopkins syndromeR01NS114086 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PHILPOT, BENJAMIN D · 2019 to 2023
$1.7MInvestigating UBE3A as a driver gene in Duplication 15q syndromeR01NS129914 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENJAMIN D PHILPOT · 2023 to 2026
$1.6MSuper Resolution STED Microscopy at UNCS10OD030300 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GUPTON, STEPHANIE · 2022 to 2022
$600kNCI NIH HHS P30 CA016086NIH HHS S10 OD030300NINDS NIH HHS R01 NS114086NINDS NIH HHS R01 NS129914NINDS NIH HHS R01 NS131615NINDS NIH HHS U24 NS124025
6 · The paper itselfAbstract
Pitt-Hopkins syndrome (PTHS) is a neurodevelopmental disorder caused by haploinsufficiency of
Identifiers
PMID41509287
PMCPMC12776099
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