Evidence map›Paper›PMID 41509281›Full record

ArticlebioRxiv : the preprint server for biology2025

Antigen-specific CD8 T cells are generated and reactivated in the bone marrow following viral brain infections and impact the bone marrow niche.

Delaney M Anani-Wolf, Kelly M Hotchkiss, Rachael A Reesman, Christian K Pfaller, Eliese M Moelker, Alexandra M Hoyt-Miggelbrink, Cori E Fain, Kathryn E Blethen, Pamela K Norberg, Shannon E Wallace and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Delaney M Anani-WolfDepartment of Neurosurgery, Duke University, Durham, NC 27710, United States.
Kelly M HotchkissDepartment of Neurosurgery, Duke University, Durham, NC 27710, United States.
Rachael A ReesmanDepartment of Neurosurgery, Duke University, Durham, NC 27710, United States.
Christian K PfallerDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, United States.
Eliese M MoelkerDepartment of Neurosurgery, Duke University, Durham, NC 27710, United States.
Alexandra M Hoyt-MiggelbrinkDepartment of Neurosurgery, Duke University, Durham, NC 27710, United States.
Cori E FainDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, United States.
Kathryn E BlethenDepartment of Neurosurgery, Duke University, Durham, NC 27710, United States.
Pamela K NorbergDepartment of Neurosurgery, Duke University, Durham, NC 27710, United States.
Shannon E WallaceDepartment of Neurosurgery, Duke University, Durham, NC 27710, United States.
Vatsal JainDepartment of Neurosurgery, Duke University, Durham, NC 27710, United States.
Gerald A GrantDepartment of Neurosurgery, Duke University, Durham, NC 27710, United States.
Mustafa KhasrawDepartment of Neurosurgery, Duke University, Durham, NC 27710, United States.
Vidyalakshmi ChandramohanDepartment of Neurosurgery, Duke University, Durham, NC 27710, United States.
Aaron J JohnsonDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, United States.
Katayoun AyasoufiDepartment of Neurosurgery, Duke University, Durham, NC 27710, United States.

Funding

CD8 T cell mediated disruption of Blood Brain Barrier Tight JunctionsR01NS103212 · NINDS · MAYO CLINIC ROCHESTER · PI Aaron J Johnson · 2017 to 2026
$4.6M
Nervous system control and regulation of the immune system following neurological insultsR00NS117799 · NINDS · DUKE UNIVERSITY · PI AYASOUFI, KATAYOUN · 2023 to 2025
$729k
Nervous system control and regulation of the immune system following neurological insultsK99NS117799 · NINDS · MAYO CLINIC ROCHESTER · PI AYASOUFI, KATAYOUN · 2021 to 2022
$209k
NINDS NIH HHS K99 NS117799NINDS NIH HHS R00 NS117799NINDS NIH HHS R01 NS103212
6 · The paper itself

Abstract

Bone marrow is the primary immune organ responsible for stem cell maintenance and hematopoiesis. However, the contribution of the bone marrow niche for the generation of adaptive immune responses is less well-understood. We therefore assessed the capacity of virus antigen-specific CD8 T cells to be generated and expanded in bone marrow following acute neurotropic virus infection. Intracranial infection with the neurotropic Theiler's Murine Encephalomyelitis Virus (TMEV) results in an acute infection in the C57BL/6 mouse which is cleared within 4 weeks post infection due to the generation of an antigen-specific CD8 T cell response against the immunodominant epitope VP2

Identifiers

PMID41509281
PMCPMC12776085

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.