Evidence map›Paper›PMID 41509278›Full record

ArticlebioRxiv : the preprint server for biology2025

Cysteine protease cathepsin B promotes high population density-induced mutagenesis, driving genome evolution and competitive growth in response to the crowding stress.

Bin Yu, Yuji Suehiro, Bryan J Johnson, Eui-Seung Lee, Dongdong Li, Yawen Huang, Joshua Johnson, Guangshuo Ou, James DeGregori, Shohei Mitani and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Bin YuDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.ORCID 0000-0001-7104-9328
Yuji SuehiroDepartment of Physiology, Tokyo Women's Medical University, School of Medicine, Tokyo, 162-8666, Japan.
Bryan J JohnsonDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Eui-Seung LeeDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
Dongdong LiTsinghua-Peking Center for Life Sciences and School of Life Sciences, Tsinghua University, Beijing, China.
Yawen HuangDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
Joshua JohnsonDepartment of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Guangshuo OuTsinghua-Peking Center for Life Sciences and School of Life Sciences, Tsinghua University, Beijing, China.ORCID 0000-0003-1512-7824
James DeGregoriDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Shohei MitaniDepartment of Physiology, Tokyo Women's Medical University, School of Medicine, Tokyo, 162-8666, Japan.ORCID 0000-0002-5710-2425
Ding XueDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.

Funding

Fundamental mechanisms of paternal mitochondrial eliminationand radiation-induced bystander effectsR35GM118188 · NIGMS · UNIVERSITY OF COLORADO · PI DING XUE · 2016 to 2026
$6.8M
Predoctoral Training in the Genetics of Development, Disease and RegenerationT32GM141742 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Bruce H Appel, Jeffrey Kyle Moore · 2021 to 2026
$1.9M
BLRD VA I01 BX004495NIGMS NIH HHS R35 GM118188NIGMS NIH HHS T32 GM141742
6 · The paper itself

Abstract

In a wide variety of species from invertebrates to mammals, overpopulation has been shown to induce low fertility and high mortality. Although density-dependent population regulation is widespread in the animal kingdom, the underlying molecular mechanisms remain poorly understood. We show here that

Identifiers

PMID41509278
PMCPMC12776066

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.