Evidence map›Paper›PMID 41509275›Full record

ArticlebioRxiv : the preprint server for biology2026

Conformational changes upon pore blocker removal reveal conductive states of TMEM16A.

Christina A Stephens, Frank V Marcoline, Christian J Peters, Michael Grabe

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Christina A StephensCardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.ORCID 0000-0001-9382-003X
Frank V MarcolineCardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.ORCID 0000-0002-8842-5470
Christian J PetersDepartment of Anatomy and Cell Biology, University of Illinois College of Medicine, Chicago, IL 60612.
Michael GrabeCardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.ORCID 0000-0003-3509-5997

Funding

Computational Studies of Sodium SymportersR01GM089740 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRABE, MICHAEL · 2011 to 2020
$2.8M
Ion permeation, lipid flipping, and membrane remodeling by TMEM16 proteinsR01GM137109 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRABE, MICHAEL · 2021 to 2024
$1.4M
Neurons of the medial habenula regulate behavioral responses to nicotine in mouseR00DA041500 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PETERS, CHRISTIAN · 2019 to 2021
$747k
High Performance Computer for Computational BiosciencesS10OD021596 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALI, ANDREJ · 2016 to 2016
$443k
NIDA NIH HHS R00 DA041500NIGMS NIH HHS R01 GM089740NIGMS NIH HHS R01 GM137109NIH HHS S10 OD021596
6 · The paper itself

Abstract

TMEM16A is a Ca

Identifiers

PMID41509275
PMCPMC12776554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.