Evidence map›Paper›PMID 41509258›Full record

ArticlebioRxiv : the preprint server for biology2026

HIV-1 Integration Site Determines the Transcriptional Fate and Persistence of Integrated Proviruses.

Virender Kumar Pal, Ali Danesh, Marie Canis, Thomas R Dilling, Itzayana G Miller, Tan Thinh Huynh, Dennis C Copertino, Douglas Barrows, Thomas Carroll, Theodora Hatziioannou and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Virender Kumar PalLaboratory of Retrovirology, The Rockefeller University, New York.ORCID 0000-0001-8378-1823
Ali DaneshDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York.
Marie CanisLaboratory of Retrovirology, The Rockefeller University, New York.
Thomas R DillingDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York.
Itzayana G MillerDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York.
Tan Thinh HuynhDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York.
Dennis C CopertinoDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York.
Douglas BarrowsBioinformatics Resource Center, The Rockefeller University, New York.
Thomas CarrollBioinformatics Resource Center, The Rockefeller University, New York.
Theodora HatziioannouLaboratory of Retrovirology, The Rockefeller University, New York.
R Brad JonesDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York.
Guinevere Q LeeDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York.ORCID 0000-0002-9412-886X
Frauke MueckschLaboratory of Retrovirology, The Rockefeller University, New York.
Paul D BieniaszLaboratory of Retrovirology, The Rockefeller University, New York.

Funding

REACH: Research Enterprise to Advance a Cure for HIVUM1AI164565 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Marina Caskey, R. Brad Jones · 2021 to 2026
$32.9M
Center for Structural Biology of HIV RNAU54AI170660 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALICE TELESNITSKY · 2022 to 2026
$32.1M
NIAID NIH HHS U54 AI170660NIAID NIH HHS UM1 AI164565
6 · The paper itself

Abstract

The mechanisms by which latent HIV-1 reservoirs persist during antiretroviral therapy is incompletely understood. Here, we derive a model system to measure clonal expansion and viral latency in which populations of human memory CD4

Identifiers

PMID41509258
PMCPMC12776120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.