Evidence map›Paper›PMID 41509253›Full record

ArticlebioRxiv : the preprint server for biology2025

A Neyman-Pearson Framework for Modeling Cellular Decision Making Using Single-Cell TNF-NF-κB Signaling Data.

Ali Emadi, Tomasz Lipniacki, Andre Levchenko, Ali Abdi

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ali EmadiArc Institute, 3181 Porter Dr, Palo Alto, CA 94304, USA.ORCID 0000-0002-2224-8854
Tomasz LipniackiInstitute of Fundamental Technological Research, Polish Academy of Sciences, Pawinskiego 5B, Warsaw, Poland.ORCID 0000-0002-3488-2561
Andre LevchenkoYale Systems Biology Institute and Department of Biomedical Engineering, Yale University, New Haven, CT, USA.ORCID 0000-0001-6262-1222
Ali AbdiCenter for Wireless Information Processing, Department of Electrical and Computer Engineering, New Jersey Institute of Technology, 323 King Blvd, Newark, NJ 07102, USA.ORCID 0000-0002-5694-6888

Funding

Systems analysis of cell-to-cell variability and signaling-transcription factor motifs regulating macrophage responses to conflicting environmental cuesR01GM123011 · NIGMS · YALE UNIVERSITY · PI MILLER-JENSEN, KATHRYN · 2017 to 2025
$2.5M
NIGMS NIH HHS R01 GM123011
6 · The paper itself

Abstract

Cells make hard calls under noise. When signaling is abnormal, those calls can go wrong and drive pathological conditions and diseases. In this research, we develop a Neyman-Pearson (NP) detection-theory framework that maximizes probability of detection (

Identifiers

PMID41509253
PMCPMC12776388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.