ArticlebioRxiv : the preprint server for biology2026
Transcriptional Heterogeneity Reveals a Synaptic Gene Program in Developing and Adult Human Oligodendrocyte Precursor Cells.
Aliya R Grinberg, Li Liu, Irva Patel, Brinda Guntur, Ian A Glass, Birth Defects Research Laboratory, Kosaku Shinoda, Hiroko Nobuta
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Aliya R GrinbergDepartment of Biology, The College of New Jersey, Ewing, NJ 08628, USA.
Li LiuDepartments of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Irva PatelDepartment of Cell Biology & Neuroscience, Rutgers University, Piscataway, NJ 08854.
Brinda GunturDepartment of Cell Biology & Neuroscience, Rutgers University, Piscataway, NJ 08854.
Ian A GlassUniversity of Washington, Seattle, WA 98105, USA.
Birth Defects Research Laboratory
Kosaku ShinodaDepartments of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Hiroko NobutaDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854, USA.
Funding
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY E. PESSIN · 2015 to 2026
$27.7MLABORATORY OF DEVELOPMENTAL BIOLOGYR24HD000836 · NICHD · UNIVERSITY OF WASHINGTON · PI Ian Amos Glass · 1995 to 2026
$16.9MThe Mediator complex in the coordinate regulation of lipogenic gene expressionR01DK110063 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ELISCOVICH, CAROLINA INES, PESSIN, JEFFREY E. · 2016 to 2025
$5.9MMolecular Mechanism of Brown Adipose Tissue RegressionR01DK128839 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI FENG, DAORONG, PESSIN, JEFFREY E. · 2021 to 2024
$2.3MMapping the Developing Beige Fat by Massively Parallel Single Cell AnalysisR00DK110426 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SHINODA, KOSAKU · 2018 to 2020
$747kSpatial and Single Cell Transcriptomics Approach to Understand Neuron-Oligodendrocyte Communication in Human Synaptic DevelopmentR21NS132013 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI NOBUTA, HIROKO · 2023 to 2024
$388kMapping the Developing Beige Fat by Massively Parallel Single Cell AnalysisK99DK110426 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHINODA, KOSAKU · 2016 to 2017
$180kNICHD NIH HHS R24 HD000836NIDDK NIH HHS K99 DK110426NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK026687NIDDK NIH HHS R00 DK110426NIDDK NIH HHS R01 DK110063NIDDK NIH HHS R01 DK128839NINDS NIH HHS R21 NS132013
6 · The paper itselfAbstract
Human oligodendrocyte precursor cells (OPCs) arise early in gestation and expand broadly during cortical development, yet the extent of their heterogeneity remains poorly defined. Here, we isolated >2,300 highly pure OPCs from post-conceptional week (PCW) 17 human cortex using an optimized PDGFRα-based immunopanning and performed single-cell RNA sequencing. Unsupervised clustering revealed four transcriptionally distinct embryonic OPC subsets, including a previously unrecognized population that expressed genes linked to synaptic development, synaptic signaling, and neuromodulation. This subset - designated embryonic synaptic OPCs (eSyn-OPCs) - comprised approximately 28.5% of all embryonic OPCs in the cortex and was characterized by robust expression of synapse-associated secreted factors (
Indexed as
human adult brainhuman brain developmentOligodendrocyteoligodendrocyte precursor cell
Identifiers
PMID41509247
PMCPMC12776387
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390