Evidence map›Paper›PMID 41509229›Full record

ArticlebioRxiv : the preprint server for biology2025

Sandeep Gupta, Eric Heinrichs, Cristian Rodriguez, Emily Friedman, Salena Gallardo, Talin Dermirjie, Teny Panosian, Keith Phan, Anooshik Tahmasian, Yahir Verdin and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sandeep GuptaDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA 90095.
Eric HeinrichsDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA 90095.
Cristian RodriguezDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA 90095.
Emily FriedmanDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA 90095.
Salena GallardoDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA 90095.
Talin DermirjieCIRM Bridges to Research Program, California State University, Northridge, CA 91330.
Teny PanosianCIRM Bridges to Research Program, California State University, Northridge, CA 91330.
Keith PhanDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA 90095.
Anooshik TahmasianCIRM Bridges to Research Program, California State University, Northridge, CA 91330.
Yahir VerdinCIRM Bridges to Research Program, California State University, Northridge, CA 91330.
Samantha J ButlerDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA 90095.ORCID 0000-0002-9491-7551

Funding

UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peyman Golshani, SUMA JACOB · 2020 to 2026
$9.6M
Training Grant in Genomic Analysis and InterpretationT32HG002536 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Valerie A Arboleda, Harold Pimentel · 2002 to 2026
$8.6M
Assessing the mechanisms directing cell fate in the dorsal spinal cordR01NS123187 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAMANTHA J BUTLER · 2022 to 2026
$2.2M
NHGRI NIH HHS T32 HG002536NICHD NIH HHS P50 HD103557NINDS NIH HHS R01 NS123187
6 · The paper itself

Abstract

Spinal cord injuries (SCI) result in the loss of motor and sensory function. We are working towards restoring sensation by developing directed differentiation protocols to generate dorsal spinal interneurons (dIs; dI1-dI6) from human embryonic stem cells (hESCs). Here, we present an improved method that produces human dIs via a neuromesodermal progenitor state, the physiological intermediate for spinal cord development. We show that retinoic acid (RA), bone morphogenetic protein 4 (BMP4) and growth differentiation factor (GDF) 11 direct dI identity, while GDF11 and extended time in culture promotes posterior spinal identities. Together, these protocols generate the full complement of dorsal subtypes along the entire anterior-posterior axis of the spinal cord. To benchmark

Indexed as

BMP4directed differentiation protocoldorsal interneuronsGDF11HOX geneshumanneuromesodermal progenitorsposteriorizationreference atlassensoryspinal cordstem cells

Identifiers

PMID41509229
PMCPMC12776051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.