Evidence map›Paper›PMID 41509216›Full record

ArticlebioRxiv : the preprint server for biology2025

Revealing the Drivers Underlying Distinct Evolutionary Trajectories in Lung Adenocarcinoma.

Christopher Wirth, Tongwu Zhang, Marcos Díaz-Gay, Christopher D Steele, Phuc H Hoang, Yang Yang, Azhar Khandekar, Wei Zhao, Jian Sang, Charles Leduc and 51 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

61 authors.

Christopher WirthManchester Cancer Research Centre, The University of Manchester, Manchester, UK.
Tongwu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Marcos Díaz-GayDigital Genomics Group, Structural Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
Christopher D SteeleDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Phuc H HoangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Yang YangBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA.
Azhar KhandekarDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Wei ZhaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jian SangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Charles LeducDepartment of Pathology, Centre Hospitalier de l'Université de Montréal, Montreal, Canada.
Marina K BaineDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
William D TravisDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lynette M ShollDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Philippe JoubertInstitut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada.
Robert HomerDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Soo-Ryum YangDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Thi-Van-Trinh TranDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
John P McElderryDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Caleb HartmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Mona MiraftabDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Olivia W LeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Kristine M JonesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Bin ZhuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jacobo Martínez SantamaríaBiobanco IBSP-CV FISABIO, Valencia, Spain.
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID 0000-0003-3241-3216
Sai S YendamuriThoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Marta ManczukDepartment of Cancer Epidemiology and Primary Prevention, Maria Skłodowska-Curie National Research Institute of Oncology, Warshaw, Poland.
Jolanta LissowskaDepartment of Cancer Epidemiology and Primary Prevention, Maria Skłodowska-Curie National Research Institute of Oncology, Warshaw, Poland.
Beata ŚwiątkowskaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland.
Anush MukeriaDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
Oxana ShanginaDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
David ZaridzeDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
Ivana HolcatovaInstitute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Vladimir JanoutFaculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic.
Dana MatesDepartment of Occupational Health and Toxicology, National Center for Environmental Risk Monitoring, National Institute of Public Health, Bucharest, Romania.
Simona OgnjanovicInternational Organisation for Cancer Prevention and Research (IOCPR), Belgrade, Serbia.
Milan SavicDepartment of Thoracic Surgery, Clinical Center of Serbia, Belgrade, Serbia.
Milica KonticClinic of Pulmonology, University Clinical Center of Serbia, Belgrade, Serbia.
Yohan BosséInstitut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada.
Bonnie E Gould RothbergSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
David C ChristianiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Valerie GaborieauGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Paul BrennanGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Geoffrey LiuPrincess Margaret Cancer Center, Temerty School of Medicine, University of Toronto, Toronto, Ontario, Canada.
Paul HofmanLaboratory of Clinical and Experimental Pathology, IHU RespirERA, FHU OncoAge, IRCAN, Biobank 0033-00025, Pasteur Hospital, University Côte d'Azur, Nice, France.
Maria Pik WongQueen Mary Hospital, The University of Hong Kong, Hong Kong, China.
Kin Chung LeungDepartment of Pathology, The University of Hong Kong, Hong Kong, China.
Chih-Yi ChenInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
I-Shou ChangNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Chao Agnes HsiungInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Angela C PesatoriDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Dario ConsonniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Martin A NowakDepartment of Mathematics, Harvard University, Cambridge, MA, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Lixing YangBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-3596-4515
David C WedgeManchester Cancer Research Centre, The University of Manchester, Manchester, UK.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5M
Studies of Genetic and Environmental EpidemiologyZIACP101231 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI LANDI, MARIA · 2018 to 2025
$23.6M
The Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2M
Intramural NIH HHS ZIA CP101231NCI NIH HHS P30 CA076292NCI NIH HHS U01 CA209414
6 · The paper itself

Abstract

Elucidating the evolution of cancers allows us to understand their key events, and the order in which they occur. To chart and interpret these evolutionary trajectories, we leverage whole-genome sequencing of lung tumours, including those from the largest cohort to date of lung cancers in subjects who have never smoked. Through ordering frequent genomic alterations, we discover three distinct evolutionary paths taken by lung adenocarcinomas; two dominated by tumours from people who have never smoked (NS-LUAD), and one followed by the vast majority of those who have smoked (S-LUAD). However, one in six NS-LUAD follow the smoking-dominant trajectory. These tumours, surprisingly, have fewer somatic alterations than the other NS-LUAD, and have shorter latency. They are strongly enriched for

Identifiers

PMID41509216
PMCPMC12776081

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