Evidence map›Paper›PMID 41509208›Full record

ArticlebioRxiv : the preprint server for biology2025

DNA polymerase I is an efficient reverse transcriptase that mediates RNA-templated DNA repair synthesis.

Frances C Lowder, Abigail H Kendal, Lyle A Simmons

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Frances C LowderDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
Abigail H KendalDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
Lyle A SimmonsDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.

Funding

Novel mechanisms of DNA repair and cell cycle regulation in bacteriaR35GM131772 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lyle Simmons · 2019 to 2026
$2.8M
NIGMS NIH HHS R35 GM131772
6 · The paper itself

Abstract

It is well established that during normal growth and under stress conditions ribonucleotides become nested in genomic DNA. Given the high frequency with which RNA is found in genomic DNA, it is unknown which DNA polymerase is responsible for catalyzing RNA-dependent DNA synthesis. In this work we establish bacterial DNA polymerase I (Pol I) as a robust reverse transcriptase. We tested several bacterial Pol I enzymes and found that all possess RT activity with

Indexed as

Bacillus subtilisDNA polymerase Igenome instabilityReverse transcriptaseRNA-DNA hybrid

Identifiers

PMID41509208
PMCPMC12776460

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.