ArticleIranian journal of otorhinolaryngology2025
The Effects of Hesperidin on the Healing Process of Cleft Lip Surgical Wounds in Rats: A Histological Evaluation and Therapeutic Analysis.
Article in Iranian journal of otorhinolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Cleft lip and palate are the most common congenital craniofacial anomalies, and inadequate treatment of these defects may lead to serious psychosocial and economic consequences. Hesperidin, a flavanone extracted from citrus fruit peels, is a potent antioxidant. However, no study has yet investigated the effects of hesperidin on surgical wound healing in cleft lips. The aim of the present study was to evaluate the histological effects of hesperidin on the healing process of surgically induced cleft lip wounds in rats. Materials and Methods: In this Results: The findings showed that the mean scores for fibroblast proliferation, collagen deposition, and inflammatory cell density were significantly higher in the placebo group compared to the 100 mg/kg hesperidin group ( Conclusion: Administration of 100 mg/kg hesperidin decreased fibroblast proliferation, collagen deposition, and inflammatory cell density, while increasing epithelial proliferation during the healing of surgically induced cleft lip wounds in rats. These results suggest that hesperidin may modulate wound repair and contribute to reduced scar formation, which could be particularly beneficial in the aesthetic zone.
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