ArticleAvicenna journal of phytomedicine
Involvement of synaptophysin and microtubule-associated protein 2 in the neuroprotective effect of berberine in an amyloid β-induced rat model of Alzheimer's disease.
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Alzheimer's disease (AD) is a major public health concern. Berberine has shown promise in animal models by improving memory retention through multiple mechanisms. This study aimed to evaluate berberine therapeutic potential in ameliorating cognitive deficits in a rat AD model induced by intrahippocampal amyloid β Materials and Methods: The AD model was induced through bilateral injection of amyloid β Results: Berberine improved the cognitive performance of amyloid-microinjected rats in the Y-maze, novel object recognition, and passive avoidance tests in a dose-dependent manner. Berberine attenuated hippocampal levels of malondialdehyde (MDA), nitrite, and tumor necrosis factor α (TNFα). Furthermore, berberine improved the activity of superoxide dismutase (SOD) and reduced caspase-3 and AChE activity. Berberine also enhanced synaptophysin and microtubule-associated protein 2 (MAP2) levels and inhibited neuronal loss in the CA1 region. Conclusion: Berberine demonstrated protective effects against amyloid β-induced cognitive deficits in a rat AD model, and these effects were associated with reduced oxidative and nitrosative stress, inflammation, apoptosis, and AChE activity, alongside enhanced synaptic protection.
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