ArticleAvicenna journal of phytomedicine
Plumbagin protects rat cortical neurons from mechanical trauma injury-induced apoptosis by inhibiting NOX4/ROS/p38 MAPK pathway.
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Overcoming Oxidative Stress in Parkinson's Disease: NADPH Oxidase 4 (NOX4) as a Potential Therapeutic Target.Antioxidants (Basel, Switzerland) · 2026Review
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Authors and funding
5 authors.
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Abstract
Objective: The aim of this study was to survey whether plumbagin (PLB), a naturally occurring naphthoquinone found in the plants of Materials and Methods: Rat primary cortical neurons were isolated from time-mated pregnant Sprague-Dawley rats and cultured Results: Our results indicated that PLB pretreatment significantly alleviated trauma induced-neuronal injury by restoring cell viability and reducing lactate dehydrogenase (LDH) leakage compared with the trauma group (p<0.01). The morphology of injured neurons was improved by PLB pretreatment. Also, PLB notably reduced ROS production in cultured rat primary cortical neurons compared with the trauma group (p<0.01). Furthermore, PLB counteracted the mechanical injury-mediated apoptosis (p<0.01) and inhibited the expression of NOX4 protein and p38 MAPK phosphorylation in cortical neurons compared with the trauma group (p<0.01). Conclusion: The present findings illustrate that PLB can alleviate mechanical trauma injury-induced apoptosis by inhibiting the NOX4/ROS/p38 MAPK pathway in primary cortical neurons.
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