Evidence map›Paper›PMID 41509119›Full record

ArticleAvicenna journal of phytomedicine

Ajiboye Oluwapelumi Micheal, Oyeleye Idowu Sunday, Adedayo Bukola Christiana, Abua Christopher Oshie, Adedeji Oluwadayomi Esther, Oboh Ganiyu

Abstract read
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In one paragraph

Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ajiboye Oluwapelumi MichealFunctional Food and Nutraceutical Unit, Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure, Ondo State, Nigeria.
Oyeleye Idowu SundayFunctional Food and Nutraceutical Unit, Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure, Ondo State, Nigeria.
Adedayo Bukola ChristianaFunctional Food and Nutraceutical Unit, Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure, Ondo State, Nigeria.
Abua Christopher OshieFunctional Food and Nutraceutical Unit, Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure, Ondo State, Nigeria.
Adedeji Oluwadayomi EstherFunctional Food and Nutraceutical Unit, Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure, Ondo State, Nigeria.
Oboh GaniyuFunctional Food and Nutraceutical Unit, Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure, Ondo State, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Erectile dysfunction (ED) is a prevalent complication among diabetic patients, and it is associated with oxidative stress, endothelial dysfunction, and diminished nitric oxide generation. This study investigates the therapeutic efficacy of alkaloid extracts from Materials and Methods: Male Wistar rats were divided into seven groups: non-diabetic control, untreated diabetic, standard drug-treated diabetic (5 mg/kg glibenclamide), and four extract-treated diabetic groups (5 and 50 mg/kg of each plant alkaloid extract). Diabetes was induced via intraperitoneal injection of streptozotocin (STZ). Treatments were administered orally, once daily, for a duration of 21 days. Results: Biochemical analysis demonstrated that diabetic rats had elevated phosphodiesterase-5 (PDE-5) and arginase activities and diminished antioxidant molecules. Treatment with plant extracts significantly inhibited PDE-5 and arginase activities, restored antioxidant enzymes (superoxide dismutase, catalase, glutathione-S-transferase, and reduced glutathione), and decreased malondialdehyde (MDA) and reactive oxygen species levels, indicating their potential to mitigate oxidative stress. The extracts had an inhibitory effect on acetylcholinesterase and butyrylcholinesterase activities, hence augmenting cholinergic signaling. Conclusion: Alkaloid extracts of

Indexed as

Andrographis paniculateDiabetes mellitusEndothelial dysfunctionErectile dysfunctionPhyllanthus amarus

Identifiers

PMID41509119
PMCPMC12777674

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.