ArticleHealth science reports2026
Adherence to Surgical Antimicrobial Prophylaxis Guidelines and Improvement Efforts: A Single-Center, Pre- and Post-Intervention Comparison Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Adherence to surgical antimicrobial prophylaxis (SAP) guidelines reduces the incidence of surgical site infections (SSIs) and improves prognosis and healthcare economics. This single-center, pre- and post-intervention comparative study investigated SAP guidelines adherence. Accordingly, we intervened where improvements were required. Changes in SAP guidelines adherence and SSI incidence were then evaluated. Methods: We assessed adherence to the appropriate antimicrobial administration timing within 1 h before skin incision in surgeries performed between April 2021 and June 2022. Regarding drug selection, dosage, and duration, we evaluated SAP protocols for 228 procedures across 18 departments and compared them with established guidelines. Results: Overall adherence to appropriate antimicrobial administration timing was 92.3% (4687/5076). Adherence was particularly low after gastroenterological surgery, cardiovascular surgery, orthopedic surgery, and neurosurgery, with a total adherence rate of 82.6% (1603/1941) across these four departments. Drug selection and duration deviated from guidelines in 25% (57/228) of procedures. The most common area requiring improvement was inappropriate drug selection in 57.9% (33/57), followed by unnecessarily long duration in 50.9% (29/57) of cases. In addition to an educational approach, a new antimicrobial initiation index, based on preoperative preparatory events, was established in low-adherence departments. All protocols requiring improvement were revised to align with established guidelines. Consequently, adherence to the appropriate antimicrobial administration timing in departments with previously low adherence improved significantly (pre-intervention: 82.6%; 95% confidence interval [CI]: 80.8%-84.2%; post-intervention: 95.0%; 95% CI: 93.8%-96.0%; Conclusion: Establishing department-specific antimicrobial initiation indexes, based on the surgical preparation stage, might be an effective measure for improving adherence to the appropriate antimicrobial administration timing in patients receiving SAP. Changes in SSI incidence require further study.
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