Evidence map›Paper›PMID 41509044›Full record

ArticleJournal of oral microbiology2026

Vendor-specific microbiomes influence oral cancer development and its response to

Doaa E El-Hadedy, Tsute Chen, Kathy Q Cai, Andres J Klein-Szanto, Anbin Mu, Kerry S Campbell, Kelly A Whelan, Nezar N Al-Hebshi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Doaa E El-HadedyDepartment of Oral Health Sciences, Oral Microbiome Research Laboratory, Maurice H. Kornberg School of Dentistry, Temple University, Philadelphia, PA, USA.
Tsute ChenThe ADA Forsyth Institute, Somerville, MA, USA.ORCID https://orcid.org/0000-0001-6689-317X
Kathy Q CaiHistopathology Facility, Fox Chase Cancer Center, Philadelphia, PA, USA.
Andres J Klein-SzantoHistopathology Facility, Fox Chase Cancer Center, Philadelphia, PA, USA.
Anbin MuFels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.
Kerry S CampbellCell Culture Facility, Fox Chase Cancer Center, Philadelphia, PA, USA.
Kelly A WhelanFels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.
Nezar N Al-HebshiDepartment of Oral Health Sciences, Oral Microbiome Research Laboratory, Maurice H. Kornberg School of Dentistry, Temple University, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0003-1841-9304

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Eric Andrew Ross · 1985 to 2026
$138.8M
Health-associated oral bacteria as anti-cancer and immunomodulatory agents in oral cancerR21DE033458 · NIDCR · TEMPLE UNIV OF THE COMMONWEALTH · PI AL-HEBSHI, NEZAR, WHELAN, KELLY A · 2024 to 2024
$470k
NCI NIH HHS P30 CA006927NIDCR NIH HHS R21 DE033458
6 · The paper itself

Abstract

Background: We previously demonstrated that Materials and methods: Oral carcinogenesis was induced using 4-NQO in C57BL/6 mice from Jackson Laboratory and Taconic Biosciences ( Results: Oral and gut microbiomes differed significantly between vendors. 4-NQO exposure induced marked microbial shifts and partial convergence of microbiome profiles. Jackson mice developed a significantly higher squamous cell carcinoma (SCC) burden. Several microbial taxa were associated with SCC, notably Conclusions: These data support

Indexed as

Carcinogenesisgastrointestinal microbiomemicemouth neoplasmsprobioticstreptococcus mitis

Identifiers

PMID41509044
PMCPMC12777837

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.