Evidence map›Paper›PMID 41509043›Full record

ArticleJournal of oral microbiology2026

Oral microbiome diversity and all-cause mortality in hypertensive adults: findings from a nationally representative cohort.

Zhe Zhou, Zichao Zhuang, Yipeng Ding, Yufan Jiang, Shu Chen, Qinglian Zhang, Hanxin Que, Jian Lin, Hui Deng, Yi Wang

Abstract read
In one paragraph

Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhe ZhouInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Zichao ZhuangInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Yipeng DingInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Yufan JiangInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Shu ChenInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Qinglian ZhangInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Hanxin QueInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Jian LinDepartment of Periodontology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Hui DengDepartment of Periodontology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Yi WangInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.ORCID https://orcid.org/0000-0002-8391-1453

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Oral microbiome diversity has been associated with general health. However, its association with long-term outcomes in hypertensive individuals remains unclear. Objectives: This study aimed to investigate whether oral microbiome diversity is associated with all-cause mortality in hypertensive individuals. Design: Data from 2,669 hypertensive individuals in the National Health and Nutrition Examination Survey (NHANES, 2009-2012) were analyzed. Oral microbiome diversity was assessed using four alpha-diversity metrics: the Simpson index, Shannon-Weiner index, Faith's Phylogenetic Diversity, and observed amplicon sequence variants (ASVs). Weighted multivariable Cox proportional hazards regression and interaction analyses were conducted. Results: During a mean follow-up of 8.61 years, 268 all-cause deaths occurred. Higher oral microbiome diversity assessed by the Simpson index (hazard ratio [HR] = 0.38; 95% confidence interval [CI], 0.20-0.75; Conclusions: Higher oral microbiome diversity is an independent protective factor for survival in patients with hypertension, with potential sex-specific differences in this association. These findings suggest that enhancing oral microbiome diversity may potentially help promote overall health in individuals with hypertension.

Indexed as

all-cause mortalityhypertensionNHANESOral microbiome diversitysurvival analysis

Identifiers

PMID41509043
PMCPMC12777801

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.