ArticleInternational journal of endocrinology2026
Association Between Systemic Immune-Inflammation Index and Thyroid Function: A Cross-Sectional Population-Based Study.
Article in International journal of endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Immunonutritional Indices, Inflammatory Markers, and Thyroid-Related Parameters in Adults with Hashimoto's Thyroiditis.Nutrients · 2026Article
- Association Between Systemic Immune-Inflammation Index and Thyroid Function: A Cross-Sectional Population-Based Study.International journal of endocrinology · 2026Article
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Authors and funding
4 authors.
Funding
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Abstract
Background: The systemic immune-inflammation index (SII), an emerging inflammatory biomarker, has been associated with various diseases, but its relationship with thyroid function remains unclear. Our study aimed to investigate the potential connections between SII and thyroid function in the U.S. population. Methods: We conducted a cross-sectional study using the National Health and Nutrition Examination Survey (NHANES) 2007-2012 data to evaluate the association between SII and thyroid function, including free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (TT3), total thyroxine (TT4), and thyroid-stimulating hormone (TSH). Furthermore, the correlation was evaluated using multiple linear regression, smooth curve fitting, and threshold effect analysis. Results: After multivariable linear regression, higher lgSII levels were independently associated with lower FT3 ( Conclusion: In U.S. adults, lgSII was negatively associated with FT3 and TSH and positively associated with TT4. These findings highlight a potential link between systemic inflammation and thyroid function, warranting further prospective studies to investigate causal relationships.
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