ArticleCurrent drug targets2026
PDMD: A Comprehensive Repository of Plants Reported for Skeletal Muscle-related Ailments.
Article in Current drug targets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 authors.
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Abstract
introductionMedicinal plants and phytocompounds targeting skeletal muscle wasting in humans are under-represented in the majority of databases reporting plant/herb-diseases association. However, a large body of literature exists wherein plant extracts or active pharmaceutical ingredients thereof demonstrate potential benefit in skeletal muscle wasting diseases across model organisms. Underscoring the relevance of a repertoire documenting such medicinal plants, we introduce PDMD (Plants Database for Muscle Wasting Diseases), a manually curated plants database reported for muscle wasting diseases such as cachexia, sarcopenia, muscle atrophy, muscle frailty, impaired muscle regeneration, and muscle fatigue.
methodsPDMD was developed through systematic manual collection and curation of published studies from PubMed, Science Direct, etc, retrieving literature on plants conferring pharmacological efficacy against muscle wasting across experimental model organisms. Phytochemical and taxonomic information were extracted via tools like ClassyFire, PubChem. To handle the storage of an annotated listing of plants, MS-Excel and MySQL were used. Frontend was designed in Visual Studio Code and HTML/CSS. An Apache/PHP server was used to integrate MS-Excel data and charts.
resultsPDMD encompasses 206 medicinal plants and 230 APIs reported across 18 model organisms, offering taxonomical information, phytochemical classes, SMILES structures, geographical distribution, and other bioactivity indications. PDMD is cross-referenced with standard databases, such as PubChem and PubMed, to enhance functionality. DISCUSSION: PDMD catalogs plant-skeletal muscle links in a user-friendly, cross-referenced, free database. PDMD bridges the gaps between ethnopharmacology and botany and aids hypothesis generation for the discovery or screening of phyto-pharmaceuticals.
conclusionPDMD highlights overlooked plant-muscle links, bridging ethnopharmacology and botany gaps, and can aid hypothesis generation. PDMD is freely available at https://www.jiit.ac.in/biotechhighlightes/Research-Databases/PDMD/index.html, and was last updated in September 2025.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.