Evidence map›Paper›PMID 41508774›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

TNF/TNFR1 is a Key Regulator of Prolonged Fasting-Induced Decrease in Adipose Tissue.

Amanda Carla Clemente de Oliveira, Adma Maciel Babêtto, Mariele Lino Silva, Larisse de Souza Barbosa Lacerda, Thiago de Souza Rodrigues, Marina Chaves de Oliveira, Christine Rouault, Emmanuel L Gautier, André Gustavo Oliveira, Karine Clément and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. TNF/TNFR1 is a Key Regulator of Prolonged Fasting-Induced Decrease in Adipose Tissue.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amanda Carla Clemente de OliveiraImmunometabolism, Department of Nutrition, Nursing School, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Adma Maciel BabêttoImmunometabolism, Department of Nutrition, Nursing School, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Mariele Lino SilvaImmunometabolism, Department of Nutrition, Nursing School, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Larisse de Souza Barbosa LacerdaImmunometabolism, Department of Nutrition, Nursing School, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Thiago de Souza RodriguesComputer Department, Federal Center for Technological Education of Minas Gerais, Belo Horizonte, Brazil.
Marina Chaves de OliveiraImmunometabolism, Department of Nutrition, Nursing School, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Christine RouaultINSERM, Nutrition and Obesities: Systemic Approach Research Group, Nutriomics, Sorbonne University, Paris, France.
Emmanuel L GautierINSERM, Nutrition and Obesities: Systemic Approach Research Group, Nutriomics, Sorbonne University, Paris, France.
André Gustavo OliveiraDepartment of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Karine ClémentINSERM, Nutrition and Obesities: Systemic Approach Research Group, Nutriomics, Sorbonne University, Paris, France.
Mauro Martins TeixeiraImmunometabolism, Department of Nutrition, Nursing School, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Geneviève MarcelinINSERM, Nutrition and Obesities: Systemic Approach Research Group, Nutriomics, Sorbonne University, Paris, France.
Adaliene Versiani Matos FerreiraImmunometabolism, Department of Nutrition, Nursing School, Federal University of Minas Gerais, Belo Horizonte, Brazil.ORCID 0000-0003-2256-8652

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) 88881.879204/2023-01Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Instituto Nacional de Ciência e Tecnologia de Nanobiofarmacêutica (INCT NanoBiofar) 406792/2022-4
6 · The paper itself

Abstract

Nutrient availability influences white adipose tissue (WAT) inflammation, leading to decreased or increased adiposity. Tumor necrosis factor (TNF) is elevated in WAT under both conditions, being involved in lipolysis and regulation of interleukin 18 (IL-18) secretion, which may regulate lipolytic processes. However, the role of these cytokines in adiposity reduction due to low energy availability remains unclear. Wild-type (WT) mice fasted for 24 h showed decreased adiposity, whereas TNFR1 knockout mice (TNFR1

Indexed as

Adipose TissueAdipose Tissue, WhiteFastingReceptors, Tumor Necrosis Factor, Type ITumor Necrosis Factor-alphaAdiposityAnimalsInterleukin-18LipolysisMaleMiceMice, Inbred C57BLMice, KnockoutInterleukin-18Receptors, Tumor Necrosis Factor, Type ITnfrsf1a protein, mouseTumor Necrosis Factor-alphaadipose tissuebariatric surgeryInterleukin‐18prolonged fastingtumor necrosis factor

Identifiers

PMID41508774
PMCPMC12784137

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.