ArticleAnnals of pediatric endocrinology & metabolism2025
Incidence of central precocious puberty and the role of body mass index in Korea.
Article in Annals of pediatric endocrinology & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Hypothalamic neuroimmune remodeling as an immunometabolic bridge between childhood obesity and earlier pubertal onset.Frontiers in immunology · 2026Review
- Early-life obesity as a risk factor for central precocious puberty - A commentary on "Incidence of central precocious puberty and the role of body mass index in Korea".Annals of pediatric endocrinology & metabolism · 2025Article
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Abstract
purposeThis study aimed to evaluate national trends in central precocious puberty (CPP) incidence in Korean children and to examine the association between early childhood obesity and CPP using linked population-based datasets.
methodsData were obtained from the National Health Insurance Service (NHIS, 2012-2020) and the Infant/Toddler Health Check-up Program (2013-2016). CPP was defined operationally as having an International Classification of Diseases, 10th Revision code for precocious puberty, NHIS registration for CPP, and at least one year of gonadotropin-releasing hormone agonist treatment initiated before age 8 in girls and 9 in boys. Children with at least 3 health screenings before 6 years of age were included for body mass index (BMI) analysis. Multivariable logistic regression was used to estimate odds ratios (ORs) for CPP across BMI categories.
resultsA total of 195,892 CPP cases were identified. The incidence of CPP increased steadily from 2012 to 2020 in both sexes. In BMI analysis (n=35,766), CPP risk was significantly higher in the overweight (85th-94th percentile) and obese (≥95th percentile) groups compared to the normal-weight group (5th-84th percentile). The association was strongest in obese boys (OR, 2.573; 95% confidence interval, 2.417-2.739). Underweight status (<5th percentile) was associated with reduced CPP risk.
conclusionCPP incidence in Korea has increased in recent years. Early childhood obesity is a strong, independent risk factor for CPP, particularly in boys. Early weight management strategies may help reduce CPP risk.a.
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