Evidence map›Paper›PMID 41508392›Full record

ArticleThe world journal of men's health2026

Age Disparity in Couples Seeking First Medical Help for Infertility Has Changed Over the Last Twenty Years: A Socio-Demographic Analysis.

Federica Passarelli, Luca Boeri, Edoardo Pozzi, Massimiliano Raffo, Fausto Negri, Federico Belladelli, Christian Corsini, Alessandro Bertini, Gabriele Birolini, Alessia D'Arma and 3 more

Abstract read
In one paragraph

Article in The world journal of men's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Federica PassarelliDepartment of Urology, IRCCS Fondazione Ca' Granda, Policlinico di Milano, Milan, Italy.ORCID https://orcid.org/0009-0008-5983-7952
Luca BoeriDepartment of Urology, IRCCS Fondazione Ca' Granda, Policlinico di Milano, Milan, Italy.ORCID https://orcid.org/0000-0003-0040-784X
Edoardo PozziDivision of Experimental Oncology, Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0002-0228-7039
Massimiliano RaffoDivision of Experimental Oncology, Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0001-6644-6521
Fausto NegriDivision of Experimental Oncology, Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0002-3677-6412
Federico BelladelliDivision of Experimental Oncology, Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0002-2165-659X
Christian CorsiniDivision of Experimental Oncology, Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0001-9603-1589
Alessandro BertiniDivision of Experimental Oncology, Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID https://orcid.org/0009-0004-4987-7898
Gabriele BiroliniVita-Salute San Raffaele University, Milan, Italy.ORCID https://orcid.org/0009-0007-4658-3001
Alessia D'ArmaDivision of Experimental Oncology, Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0002-4855-4577
Emanuele MontanariDepartment of Urology, IRCCS Fondazione Ca' Granda, Policlinico di Milano, Milan, Italy.ORCID https://orcid.org/0000-0002-3586-666X
Francesco MontorsiDivision of Experimental Oncology, Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0002-7267-4181
Andrea SaloniaDivision of Experimental Oncology, Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0002-0595-7165

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEpidemiological studies have suggested that men are usually coupled with younger women. Parental age at first child have steadily increased over last decades. Accordingly, the age gap within partners has changed in the real-life setting over the same time frame. To analyze differences in partners' age (delta [Δ] age [M-F]) over a 20-year time frame among 1,605 men and their partners, seeking medical help for primary couple's infertility at a single center (2005-2024). MATERIALS AND

methodsPartners' age was recorded, Δage was calculated. Comorbidities were scored with Charlson Comorbidity Index (CCI). Educational status was recorded. Sexual dysfunctions were self-reported for all male patients. Descriptive statistics and linear regression analyses were applied.

resultsMedian (interquartile range) patient's and partner's age were 37 (34-41) and 34 (31-37) years. Median Δage was 3 (0-6) years. Δage decreased by 1 point for each decade, being similar between 2005-2010 and 2011-2015, then decreasing from 2016-2020 to 2011-2015 and from 2021-2024 to 2011-2015 (all p<0.01). Similar values were found between 2021-2024 and 2016-2020, suggesting 2015 as a cutoff after which Δage decreased compared to earlier years, thus remaining afterwards stable. Δage change was related to increasing age bands of the female partner since male age was similar across the time frame. Men with low education status, with CCI ≥1 and with sedentary lifestyle had higher Δage (all p<0.01). Infertile men who self-reported erectile dysfunction had higher Δage than those with normal erectile function (p=0.01).

conclusionsIn infertile couples, age-difference relationships decreased over time due to female ageing at first parenthood. Greater Δage was linked to lower education, higher comorbidities, and a sedentary lifestyle in male partners. Erectile dysfunction was more common in couples with higher Δage.

Indexed as

ComorbidityDemographyInfertilityRisk factorsSociology

Identifiers

PMID41508392
PMCPMC13302990

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.