Evidence map›Paper›PMID 41508384›Full record

ArticleThe world journal of men's health2026

The Effect of Intratesticular Platelet-Rich Plasma Injection on Sperm Retrieval Rates in Non-Obstructive Azoospermia Male after Failed Testicular Sperm Extraction: An Inception Cohort.

Satvir S Basran, Fausto Negri, Ashkan P Langroudi, Nicholas Sellke, James Stinson, Albert Ha, Wade Muncey, Federico Belladelli, Chiyuan A Zhang, Francesco Del Giudice and 2 more

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In one paragraph

Article in The world journal of men's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Satvir S Basran *Department of Urology, School of Medicine, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0000-0003-4744-2853
Fausto Negri *Department of Urology, School of Medicine, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0000-0002-3677-6412
Ashkan P LangroudiDepartment of Urology, School of Medicine, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0000-0002-0788-2646
Nicholas SellkeDepartment of Urology, School of Medicine, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0000-0001-9378-8666
James StinsonDepartment of Urology, School of Medicine, Stanford University, Stanford, CA, USA.
Albert HaDepartment of Urology, School of Medicine, Stanford University, Stanford, CA, USA.
Wade MunceyDepartment of Urology, School of Medicine, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0000-0001-8323-7094
Federico BelladelliUniversity Vita-Salute San Rafaele, Milan, Italy; Division of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0002-2165-659X
Chiyuan A ZhangDepartment of Urology, School of Medicine, Stanford University, Stanford, CA, USA.
Francesco Del GiudiceDepartment of Maternal Infant and Urologic Sciences, Policlinico Umberto I Hospital, 'Sapienza' University of Rome, Italy.ORCID https://orcid.org/0000-0003-3865-5988
Lusine AghajanovaDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0000-0002-3515-9252
Michael L EisenbergDepartment of Urology, School of Medicine, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0000-0001-5482-0141

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWhile sperm recovery was demonstrated in males who failed prior testicular sperm extractions, the role and efficacy of autologous platelet-rich plasma (PRP) in males with non-obstructive azoospermia (NOA) undergoing salvage microdissection testicular sperm extraction (mTESE) still need to be determined. MATERIALS AND

methodsPatients with a history of NOA and at least one previous failed surgical sperm extraction were invited to participate in this study. We analyzed data from an inception cohort of 29 infertile males from January 2023 to February 2025. The primary endpoint was sperm retrieval (SR) rate at surgery. An Arteriocyte Magellan kit was used for the PRP preparation. After injecting local anesthesia as a spermatic cord block, up to 1.5 mL of the PRP mixture was injected into each testicle. After at least 90 days post-injection, microscopic-assisted testicular sperm extraction was performed. We assessed changes in serum hormone levels-specifically circulating total testosterone (TT), follicle-stimulating hormone, luteinizing hormone, and estradiol-following intratesticular PRP injection.

resultsIn total, 4 out of 25 males (16.0%) had positive SR (3/20 [15.0%] with a single previous procedure, 1/3 [33.3%] with two prior procedures, and 0/2 [0%] with three prior procedures). No change in TT was noted after PRP treatment. Patients with successful SR had higher body mass index at baseline (30.1 [29.1 to 36.1]

conclusionsAutologous intratesticular PRP injection is a feasible, well tolerated procedure with a low complication rate and rapid recovery. However, the current scientific evidence is not yet sufficient to establish its efficacy in the context of mTESE.

Indexed as

AzoospermiaInfertility, malePlatelet-rich plasmaSperm retrieval

Identifiers

PMID41508384
PMCPMC13646301

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.