Evidence map›Paper›PMID 41508039›Full record

ArticleMolecular brain2026

Proteasome inhibition by VR23 enhances autophagic clearance of FUS

Seong Hyun Kim, Jun Hee So, Yong Hwan Kim, Hyo-Sung Kim, Na Yeon Park, Joon Bum Kim, Doo Sin Jo, Eunbyul Yeom, Jin-A Lee, Ji-Eun Bae and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Seong Hyun KimSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Republic of Korea.
Jun Hee SoSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Republic of Korea.
Yong Hwan KimSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Republic of Korea.
Hyo-Sung KimSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Republic of Korea.
Na Yeon ParkOrganelle Institute, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Republic of Korea.
Joon Bum KimOrganelle Institute, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Republic of Korea.
Doo Sin JoOrgasis Corp., Suwon, Gyeonggi-do, Republic of Korea.
Eunbyul YeomSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Republic of Korea.
Jin-A LeeDepartment of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon, Republic of Korea.
Ji-Eun BaeOrganelle Institute, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Republic of Korea. jieunbae@knu.ac.kr.
Dong-Hyung ChoSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, Republic of Korea. dhcho@knu.ac.kr.

Funding

Ministry of Education RS-2024-00463344Ministry of Trade, Industry and Energy P0025489
6 · The paper itself

Abstract

Autophagy is a conserved catabolic pathway that preserves cellular homeostasis through lysosomal degradation. Beyond its general role in proteostasis, selective autophagy mediates the clearance of selective cellular targets such as persistent stress granules (SGs), in a process termed granulophagy. SGs are dynamic cytoplasmic assemblies that normally disassemble after stress relief; however, their aberrant persistence has arisen as a pathological feature of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). However, the molecular regulation of granulophagy remains incompletely understood. Here, we established a tandem fluorescent SG reporter system with mCherry-pHluorin-FUS

Indexed as

AutophagyProteasome Endopeptidase ComplexProteasome InhibitorsStress GranulesCell Line, TumorDNA HelicasesHumansLysosomesMacrolidesPoly-ADP-Ribose Binding ProteinsRNA HelicasesRNA Recognition Motif Proteinsbafilomycin A1DNA HelicasesG3BP1 protein, humanMacrolidesPoly-ADP-Ribose Binding ProteinsProteasome Endopeptidase ComplexProteasome InhibitorsRNA HelicasesRNA Recognition Motif ProteinsFUSGranulophagySelective autophagyStress granulesVR23

Identifiers

PMID41508039
PMCPMC12870388

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.