Evidence map›Paper›PMID 41507969›Full record

ArticleTrials2026

Study protocol for a pragmatic, cluster, randomized controlled trial of a multifaceted fracture prevention model for long-term care: the PREVENT trial.

Alexandra Papaioannou, Sidney Feldman, Paul Katz, Andrew P Costa, Courtney C Kennedy, Jonathan D Adachi, Hugh Boyd, Lora Giangregorio, George Heckman, Patricia Hewston and 26 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04947722 (The PREVENT Trial), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04947722 naactive not recruitingnot on this map

The PREVENT Trial: a Pragmatic Cluster Randomized Controlled Trial of a Multifaceted Fracture Prevention Model for Long-term Care

TypeinterventionalSponsorMcMaster UniversityRan2024 to 2027Enrolled3,060ConditionsFracture, Fractures, Hip, OsteoporosisArmsPREVENT Program
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Alexandra PapaioannouGeras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada. papaioannou@hhsc.ca.ORCID http://orcid.org/0000-0001-9412-0932
Sidney FeldmanDepartment of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.
Paul KatzDepartment of Geriatrics, Florida State University, Tallahassee, FL, USA.
Andrew P CostaDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Courtney C KennedyGeras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.
Jonathan D AdachiDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Hugh BoydDepartment of Family Medicine, McMaster University, Hamilton, Ontario, Canada.
Lora GiangregorioDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.
George HeckmanDepartment of Medicine, Western University, London, Ontario, Canada.
Patricia HewstonGeras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.
John HirdesSchool of Public Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.
Jayna Holroyd-LeducDepartment of Medicine, University of Calgary, Calgary, Alberta, Canada.
Michelle HowardDepartment of Family Medicine, McMaster University, Hamilton, Ontario, Canada.
Joanne HoGeras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.
Susan JaglalDepartment of Physical Therapy, University of Toronto, Toronto, Ontario, Canada.
Sharon KaasalainenSchool of Nursing, McMaster University, Hamilton, Ontario, Canada.
Lorand KristofDepartment of Family Medicine, McMaster University, Hamilton, Ontario, Canada.
Arthur LauDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Justin LeeGeras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.
Caitlin McArthurSchool of Rehabilitation Science, Dalhousie University, Halifax, Nova Scotia, Canada.
Sharon MarrGeras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.
Denis O'DonnellCareRx Corporation, Toronto, ON, Canada.
Isabel B RodriguesDepartment of Community Health Services, University of Manitoba, Winnipeg, Manitoba, Canada.
Kanwal ShankardassThrive Group, Hamilton, Ontario, Canada.
Henry SiuDepartment of Family Medicine, McMaster University, Hamilton, Ontario, Canada.
Sharon StrausDepartment of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
Samuel ThrallDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Jean-Eric TarrideDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Lehana ThabaneDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Shuaib HafidDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Jennifer TungGeriMedRisk, Hamilton, ON, Canada.
Loretta M HillierGeras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.
Lauren L KaneGeras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.
Ashlee M AzizudinGeras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.
Teshan Dias DesingheGeras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.
George IoannidisGeras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.

Funding

Canadian Institutes of Health Research (CIHR) 175318
6 · The paper itself

Abstract

backgroundEach year, half of all long-term care (LTC) residents will sustain a fall, and many will sustain a fall-related fracture. Fifty percent of all fractures in this vulnerable cohort occur at the hip, which is a life-changing health event leading to hospitalization, impaired physical functioning, and increased risk of premature mortality. National osteoporosis guidelines for the prevention of fractures are not consistently used in LTC homes. Improving osteoporosis guideline implementation may prevent hip fractures and other fractures. This study will examine whether the PREVENT (Person-centered Routine fracture prEVENTion) model can reduce hip fracture rates over one year compared to usual care in LTC homes.

methodsOur study design is a pragmatic, cluster, randomized controlled trial. We will recruit 122 for-profit and not-for-profit LTC homes across Ontario, Canada. Homes will be randomized in a 1:1 ratio to intervention (PREVENT model) or control (usual care) arms. Eligibility criteria include a minimum of 50 occupied beds and access to the PointClickCare (PCC) electronic medical record system. One or two local opinion leader(s) and a leadership team consisting of five to ten healthcare providers will be recruited within each LTC home to support the implementation of the fracture prevention knowledge translation (KT) intervention. Generalized estimating equations (GEE) will be used to examine the effect of the PREVENT intervention vs usual care on hip fracture incidence (primary outcome), adjusting for important resident and LTC home characteristics; and secondary outcomes, including new osteoporosis medication prescriptions, non-hip fracture rates, falls, hospitalizations, death, LTC quality indicators, pain, mobility, responsive behaviors, and healthcare utilization costs. The Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) statement was used to guide the development of this study protocol. DISCUSSION: Preventing hip fractures in LTC has significant health, economic, and personal benefits. To our knowledge, the PREVENT trial is the first KT study of its kind in LTC to measure hip fracture as the primary outcome. If the PREVENT trial successfully improves hip fracture rates, it may lead the way for implementing a standardized approach to preventing hip fractures in LTC homes across Canada and internationally.

trial registrationClinicalTrials.gov NCT04947722. Registered on July 1, 2021.

Indexed as

Accidental FallsHip FracturesHomes for the AgedLong-Term CareNursing HomesOsteoporotic FracturesHumansNursing Home ResidentsOntarioPragmatic Clinical Trials as TopicProximal Femoral FracturesRisk FactorsTime FactorsTreatment OutcomeAudit and feedbackFallsHip fracturesInterdisciplinaryKnowledge translationLong-term careOsteoporosisPrevention

Identifiers

PMID41507969
PMCPMC12882496

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.