Evidence map›Paper›PMID 41507957›Full record

ArticleTrials2026

Integrating nonpharmacologic strategies for pain with Inclusion, Respect, and Equity (INSPIRE): a digital health study protocol for a pragmatic multisite randomized controlled trial.

Jesse Ristau, Agatha Okobi, Matthew J Miller, Jing Cheng, Sibel Deviren, Eleanor Bimla Schwarz, Tess Fairchild, Janice Y Tsoh, Adrian Aguilera, Cindy J Zheng-Huang and 1 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06183281 (Integrating Nonpharmacologic Strategies for Pain With Inclusion, Respect, and Equity), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06183281 narecruitingnot on this map

Integrating Nonpharmacologic Strategies for Pain With Inclusion, Respect, and Equity (INSPIRE): Tailored Digital Tools, Telehealth Coaching, and Primary Care Coordination

TypeinterventionalSponsorUniversity of California, San FranciscoRan2025 to 2028Enrolled586ConditionsChronic PainArmsCBT, Mindfulness, and Movement
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jesse RistauDepartment of Medicine, Division of General Internal Medicine, University of California, 1701 Divisadero St., Suite 500, San Francisco, CA, 94115, USA.
Agatha OkobiDepartment of Medicine, Division of General Internal Medicine, University of California, 1701 Divisadero St., Suite 500, San Francisco, CA, 94115, USA.
Matthew J MillerDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA.
Jing ChengDepartment of Preventive and Restorative Dental Sciences, University of California, San Francisco, CA, USA.
Sibel DevirenDepartment of Orthopedic Surgery, Spine Center, University of California, San Francisco, CA, USA.
Eleanor Bimla SchwarzDepartment of Medicine, Division of General Internal Medicine, University of California, 1701 Divisadero St., Suite 500, San Francisco, CA, 94115, USA.
Tess FairchildDepartment of Medicine, Division of General Internal Medicine, University of California, 1701 Divisadero St., Suite 500, San Francisco, CA, 94115, USA.
Janice Y TsohDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Adrian AguileraSchool of Social Welfare, University of California, Berkeley, CA, USA.
Cindy J Zheng-HuangDepartment of Medicine, Division of General Internal Medicine, University of California, 1701 Divisadero St., Suite 500, San Francisco, CA, 94115, USA.
Jason M SatterfieldDepartment of Medicine, Division of General Internal Medicine, University of California, 1701 Divisadero St., Suite 500, San Francisco, CA, 94115, USA. Jason.Satterfield@ucsf.edu.ORCID http://orcid.org/0000-0002-2765-3701

Funding

Integrating Nonpharmacologic Strategies for Pain with Inclusion, Respect, and Equity (INSPIRE): Tailored digital tools, telehealth coaching, and primary care coordinationR33NS129050 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SATTERFIELD, JASON M · 2024 to 2024
$4.8M
Tailoring Rehabilitation to the needs of Older Adults with Cognitive Impairment and DementiaK76AG083308 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Matthew Miller · 2024 to 2026
$729k
NIA NIH HHS K76 AG083308NINDS NIH HHS 4R33NS129050-02NINDS NIH HHS R33 NS129050
6 · The paper itself

Abstract

backgroundChronic pain (CP) is among the most common medical conditions, is the leading cause of disability, and is often refractory to medical treatment. The CDC and the American College of Physicians recommend nonopioid and nonpharmacologic treatment as first-line strategies, including cognitive-behavioral therapy (CBT), mindfulness-based interventions (MBI), and movement-focused interventions (MFI); however, only 3% of people with chronic pain (CP) have access to these evidence-based treatments. Patients from historically minoritized populations and those speaking languages other than English are particularly underserved and may go untreated. Stigma regarding CP and interventions to manage it present additional obstacles.

methodsThe Integrating Nonpharmacologic Strategies for Pain with Inclusion, Respect, and Equity (INSPIRE) study evaluates a blend of these non-pharmacologic, evidence-based interventions using a pragmatic, parallel, two-arm RCT comparing intervention participants with wait-list controls. The INSPIRE intervention includes a 12-week curriculum delivered via a multilingual mobile app paired with weekly telehealth coaching. The primary outcome will be the "Pain, Enjoyment, and General Activity (PEG)" scores at 3 months. Secondary outcomes include PEG scores at 6 and 12 months, physical functioning, quality of life, sleep, depression, anxiety, and global satisfaction with treatment at 3, 6, and 12 months. Primary mediators to be examined include pain cognitions and health behaviors. Secondary mediators may include stigma and isolation, trust in healthcare providers, and both engagement and satisfaction with the INSPIRE intervention. The intention-to-treat primary analysis will be conducted with covariates including baseline measures of pain, anxiety, and physical function. DISCUSSION: The full RCT protocol and intervention details are provided following the SPIRIT guidelines. Implications for improving treatment access via culturally and linguistically tailored digital health interventions are discussed along with the potential for health coaching to drive mobile app engagement.

trial registrationClinicalTrials.gov ID NCT06183281. Trial registration data set can be found here: https://clinicaltrials.gov/study/NCT06183281 and in Additional file 1.

Indexed as

Chronic PainCognitive Behavioral TherapyMindfulnessPain ManagementDigital HealthHumansMobile ApplicationsMulticenter Studies as TopicPain MeasurementPragmatic Clinical Trials as TopicQuality of LifeTelemedicineTreatment OutcomeChronic painCognitive behavioral therapyDigital healthHealth coachingHealth equityMindfulnessMovement

Identifiers

PMID41507957
PMCPMC12882389

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.