Evidence map›Paper›PMID 41507840›Full record

ArticleBMC infectious diseases2026

Genomic diversity of SARS-CoV-2 carriage in a cohort of schoolchildren in Côte d'ivoire during COVID-19 pandemics: insights from pre-delta emergence.

Kouassi Firmin Missa, Kanny Diallo, Kolotioloman Jérémie Tuo, Kouakou Brice Bla, Tiémélé Laurent-Simon Amoikon, Kossia Debia Thérèse Gboko, Amelan Marie-Flore Didia, Ganna Kovalenko, Biego Guillaume Gragnon, Joyce Mwongeli Ngoi and 4 more

Abstract read
In one paragraph

Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kouassi Firmin MissaCentre Suisse de Recherches Scientifiques en Côte d'Ivoire (CSRS), Abidjan, Côte d'Ivoire.
Kanny DialloCentre Suisse de Recherches Scientifiques en Côte d'Ivoire (CSRS), Abidjan, Côte d'Ivoire. kanny.diallo@csrs.ci.
Kolotioloman Jérémie TuoCentre Suisse de Recherches Scientifiques en Côte d'Ivoire (CSRS), Abidjan, Côte d'Ivoire.
Kouakou Brice BlaBiology and Health Laboratory, UFR Biosciences, Félix Houphouët-Boigny University (UFHB), Abidjan, Côte d'Ivoire.
Tiémélé Laurent-Simon AmoikonCentre Suisse de Recherches Scientifiques en Côte d'Ivoire (CSRS), Abidjan, Côte d'Ivoire.
Kossia Debia Thérèse GbokoCentre Suisse de Recherches Scientifiques en Côte d'Ivoire (CSRS), Abidjan, Côte d'Ivoire.
Amelan Marie-Flore DidiaCentre Suisse de Recherches Scientifiques en Côte d'Ivoire (CSRS), Abidjan, Côte d'Ivoire.
Ganna KovalenkoDivision of Virology, Department of Pathology, University of Cambridge, Cambridge, UK.
Biego Guillaume GragnonNational Laboratory for Agricultural Development Support (LANADA), Regional Laboratory of Korhogo, Korhogo, Côte d'Ivoire.
Joyce Mwongeli NgoiWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
Ian GoodfellowDivision of Virology, Department of Pathology, University of Cambridge, Cambridge, UK.
Robert WilkinsonThe Francis Crick Institute, London, NW1 1AT, UK.
Gordon AwandareWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
Bassirou BonfohCentre Suisse de Recherches Scientifiques en Côte d'Ivoire (CSRS), Abidjan, Côte d'Ivoire.

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundAfter the first case of COVID-19 was reported in Côte d’Ivoire in March 2020, the virus spread significantly, with several epidemic waves. During a carriage study conducted from November 2020 to April 2021 to examine the oropharyngeal microbiome of school children, the presence of several other pathogens was investigated. This study characterised the diversity of SARS-CoV-2 detected in a cohort of school children in Côte d’Ivoire.

methodsOropharyngeal swabs from participants in Korhogo (n = 37) and Abidjan (n = 39) were analysed. RNA was extracted from the samples, followed by RT-qPCR detection of Coronaviruses. Sequencing was done on an Oxford Nanopore platform and data analysed in GISAID.

resultsOut of 445 samples collected, 15 (3.37%; 5 in Abidjan and 10 in Korhogo) tested positive for SARS-CoV-2 and were sequenced. Genomic coverage of over 70% was obtained for 12 genome sequences (80%). There was a significant difference in SARS-CoV-2 carriage over season per sampling visit (p < 0.05). The variants identified were of type Eta and Beta, including variant of concern (VOC) B.1.351 (6.7%), Variants of Interest (VOI) B.1.525 (60%) and other unclassified lineages B.1.1.318 (6.7%), A.19 (13,3%) and A.27 (13,3%). D614G mutation (n = 11, 73,33%) located on the S gene was the most common, followed by the T205I (n = 8, 53,33%) located on the N gene in this collection of genomes.

conclusionsThis study highlights the diversity of SARS-CoV-2 that circulated in a cohort of children in Côte d’Ivoire and reports carriage of the A.19 lineage, a variant which circulated more frequently in West Africa during the study period. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Carrier StateCOVID-19Genome, ViralSARS-CoV-2ChildCohort StudiesCote d'IvoireFemaleGenetic VariationHumansMaleOropharynxPandemicsRNA, ViralRNA, ViralAbidjanGenomicKorhogoMutationOxford Nanopore TechnologyRT-qPCRSARS-CoV-2

Identifiers

PMID41507840
PMCPMC12870052

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.