ArticleBMC gastroenterology2026
Depression and risk of gastro-oesophageal reflux disease (GERD): results from the UK Biobank study.
Article in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Dietary index for gut microbiota and risk of incident gastroesophageal reflux disease: a prospective cohort analysis integrating plasma proteomics in the UK Biobank.Frontiers in nutrition · 2026Article
- Metabolomic dysregulation in the association between major depressive disorder and chronic pancreatitis: a large prospective cohort study.Frontiers in nutrition · 2026Article
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5 authors.
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Abstract
backgroundThis study investigated the association between depression and the incidence of gastro-oesophageal reflux disease (GERD) and examined whether the association interacts with age. The analysis was based on 457,958 participants aged 37–73 years from the UK-Biobank prospective cohort study.
methodsThe baseline examination started 2006 and the participants were followed up until 2019–2023 (median follow-up time 13.52 years [interquartile range12.62–14.27]). Depression at baseline and incident GERD at follow-up were defined through sources of the British health system (ICD-codes) and self-report. Multivariable adjusted Cox regression models were used for analysis. Formal tests for interaction with sex and age were conducted.
resultsParticipants who developed GERD during follow-up were characterized by an unhealthier lifestyle and more comorbidities than individuals without GERD. In multivariable analysis, depression was associated with incident GERD (Hazard ratio 1.51 [1.46,1.55]; P < 0.001). The association decreased with increasing age. There was no interaction with sex.
conclusionDepression and its psycho-physiological consequences may be associated with the development of GERD, in particular in middle-aged people. Consequently, increased attention of the treating physicians regarding an increased risk of GERD in depressed persons is important.
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